C14orf23 Inhibitors
C14orf23 inhibitors encompass a variety of chemical compounds that exert their inhibitory effects through diverse mechanisms impacting phosphorylation, protein synthesis, and cell signaling pathways. For instance, certain kinase inhibitors specifically target phosphorylation processes that are critical for maintaining the activity of C14orf23. The disruption of these processes leads to a consequential decline in C14orf23's function. Similarly, inhibitors that target the PI3K/Akt and MAPK/ERK pathways induce a downstream effect that can diminish the functional activity of C14orf23 through altered post-translational modifications or by impeding signaling cascades that regulate its activity. Moreover, a subset of these compounds interferes with the mTOR signaling, which is intricately connected to the regulation of protein synthesis and could indirectly affect the synthesis of C14orf23, leading to a decrease in its functional activity.
Further contributing to the modulation of C14orf23's function are inhibitors that affect proteostasis and epigenetic regulation. Proteasome inhibitors, for example, obstruct the degradation process of proteins, altering the levels and activity of regulatory proteins that control the activity of C14orf23. This interference results in the indirect inhibition of C14orf23's functional activity. Additionally, epigenetic modulators that affect the acetylation status of histones may indirectly govern the functional activity of C14orf23 by inducing changes in chromatin structure and affecting gene expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
This kinase inhibitor disrupts phosphorylation processes essential for many signaling pathways. Its inhibition of kinases that phosphorylate C14orf23 leads to a reduction in C14orf23's functional activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A potent inhibitor of PI3K, LY 294002, leads to a decrease in the PI3K/Akt signaling pathway, which is a pathway that can regulate the activity of C14orf23 through post-translational modifications. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
This mTOR inhibitor prevents the activation of mTORC1, which is involved in the regulation of protein synthesis and could impact the synthesis and function of C14orf23 indirectly by modulating related signaling pathways. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
As a p38 MAPK inhibitor, SB 203580 can interfere with the MAPK signaling cascade that may be involved in the regulation of C14orf23 activity, leading to its decreased functional activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
This MEK inhibitor impedes the MAPK/ERK pathway, which may regulate C14orf23 indirectly by affecting downstream signaling mechanisms that control C14orf23's activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
By inhibiting PI3K, Wortmannin suppresses the PI3K/Akt pathway that can regulate C14orf23 activity, leading to indirect inhibition of C14orf23's function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK, SP600125, interferes with the JNK signaling pathway, which can regulate cellular processes that affect C14orf23's activity, leading to its functional inhibition. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
This proteasome inhibitor can disrupt protein degradation pathways that regulate the levels of C14orf23, thus affecting its functional activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
As a histone deacetylase inhibitor, Trichostatin A changes the acetylation status of histones that can impact the chromatin structure and indirectly affect the functional activity of C14orf23 through epigenetic regulation. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 inhibits the proteasome, leading to an accumulation of proteins that may include regulatory proteins controlling C14orf23 activity, thereby decreasing its functional activity through indirect proteostatic interference. | ||||||