C14orf106 Inhibitors
MIS18 binding protein 1, is a crucial component of the cell cycle, specifically involved in the regulation of chromosome segregation during mitosis. This protein is best known for its role in the recruitment and localization of the MIS18 complex to centromeres, which are key regions of chromosomes that play a significant role in ensuring accurate chromosome alignment and segregation.MIS18BP1 interacts with the MIS18 complex, which consists of MIS18α and MIS18β, and this interaction is essential for the establishment of centromeric chromatin by enabling the loading of the CENP-A nucleosome. CENP-A is a histone H3 variant that is specifically found at centromeres and is critical for the assembly of the kinetochore, a structure on the chromosome that attaches to microtubules to pull chromosomes apart during cell division.
The proper localization and functioning of MIS18BP1 are fundamental to the centromere's identity and maintenance throughout the cell cycle. Defects in this process can lead to chromosomal instability, a hallmark of many cancer cells, where chromosomes are not appropriately segregated, leading to aneuploidy, or an abnormal number of chromosomes in daughter cells.Research into MIS18BP1 has revealed that it is highly regulated and that its expression peaks during specific phases of the cell cycle, indicating a tightly controlled mechanism for centromere specification and maintenance. Understanding the precise molecular interactions and regulation of MIS18BP1 is of particular interest in the field of cell biology, as it may uncover new targets for cancer therapy by exploiting the pathways that govern chromosome segregation.The function of MIS18BP1 extends beyond its role in mitosis, potentially influencing epigenetic regulation and the spatial organization of the genome within the cell nucleus. Consequently, MIS18BP1 is not only a critical factor in maintaining genomic stability but also a potential key player in the broader context of chromatin dynamics and nuclear architecture.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D inhibits RNA synthesis by intercalating into DNA, preventing transcription of the MIS18 binding protein 1 gene. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide inhibits protein synthesis by disrupting peptide bond formation, leading to reduced expression of MIS18 binding protein 1. | ||||||
Puromycin | 53-79-2 | sc-205821 sc-205821A | 10 mg 25 mg | $166.00 $322.00 | 436 | |
Puromycin incorporates into growing polypeptide chains, leading to premature termination of protein synthesis, hence inhibiting MIS18BP1 expression. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-Fluorouracil is a pyrimidine analog that disrupts RNA synthesis, inhibiting expression of the MIS18 binding protein 1 gene. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A inhibits histone deacetylases, leading to altered chromatin structure and gene expression, potentially inhibiting MIS18BP1 expression. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin inhibits bacterial RNA polymerase, potentially affecting transcription of the MIS18 binding protein 1 gene in bacterial expression systems. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide inhibits RNA polymerase I, II, and III, leading to reduced expression of various genes, potentially including MIS18BP1. | ||||||
Ellipticine | 519-23-3 | sc-200878 sc-200878A | 10 mg 50 mg | $145.00 $569.00 | 4 | |
Ellipticine intercalates into DNA and inhibits topoisomerase II, leading to reduced gene transcription, potentially affecting expression of MIS18 binding protein 1. | ||||||
Ethidium bromide | 1239-45-8 | sc-203735 sc-203735A sc-203735B sc-203735C | 1 g 5 g 25 g 100 g | $48.00 $150.00 $588.00 $2086.00 | 12 | |
Ethidium bromide intercalates into DNA, leading to inhibition of DNA replication and gene transcription, potentially affecting expression of MIS18 binding protein 1. | ||||||