The chemical class designated as C14orf106 activators encompasses a spectrum of compounds that influence various cellular processes including chromosome segregation, centromere and kinetochore function, and cell cycle progression. The action of these activators is rooted in their ability to modulate the intracellular pathways that C14orf106 is involved in, specifically targeting the spindle assembly checkpoint, the dynamics of microtubule stabilization, and the regulation of kinetochore attachment to microtubules. The molecular mechanisms by which these activators operate include the inhibition or stabilization of microtubule dynamics, the alteration of kinase activity that is pivotal for centromere and kinetochore maintenance, and the modulation of epigenetic markers that dictate the transcriptional landscape of proteins necessary for chromosome segregation.
In detail, C14orf106 activators comprise inhibitors of enzymes such as Aurora kinases and CDKs, which play a crucial role in the phosphorylation processes pivotal to chromosome alignment and segregation. Additionally, they include compounds that disrupt microtubule polymerization, thereby affecting spindle formation and function. The balance of kinase activities and microtubule dynamics is thus altered, which can lead to the activation of the spindle assembly checkpoint and influence the function of C14orf106 in ensuring proper chromosome segregation during mitosis. Moreover, these activators also encapsulate agents that can induce changes in chromatin architecture and histone modification patterns, thereby indirectly influencing the expression and function of C14orf106. The precise modulation of gene expression and protein function by these activators is critical, as it allows for the fine-tuning of the complex events that govern mitotic progression and genomic stability.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Stabilizes microtubules and could activate MIS18BP1-associated kinetochore function due to its role in chromosome segregation. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Microtubule polymerization inhibitor, which can disrupt spindle formation and could activate the spindle assembly checkpoint, influencing C14orf106's role in chromosome segregation. | ||||||
Tozasertib | 639089-54-6 | sc-358750 sc-358750A | 25 mg 50 mg | $61.00 $85.00 | 4 | |
Aurora kinase inhibitor that could activate centromere and kinetochore function, altering C14orf106 activity related to CENP-A loading. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
DNA methyltransferase inhibitor that could activate epigenetic changes, affecting the expression of genes coding for proteins involved in centromere function, including C14orf106. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Histone deacetylase inhibitor that could activate changes in chromatin structure, affecting centromere and kinetochore assembly, thus impacting C14orf106 function. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
CDK inhibitor that could activate effects on cell cycle progression, consequently influencing C14orf106's role in centromere function during the cell cycle. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
Aurora kinase inhibitor that could activate changes in phosphorylation events at the centromere/kinetochore complex, impacting C14orf106 function. | ||||||
BI6727 | 755038-65-4 | sc-364432 sc-364432A sc-364432B sc-364432C sc-364432D | 5 mg 50 mg 100 mg 500 mg 1 g | $147.00 $1029.00 $1632.00 $3264.00 $4296.00 | 1 | |
PLK1 inhibitor that could activate interference with spindle formation and checkpoint function, altering C14orf106 activity at the kinetochore. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Kinesin Eg5 inhibitor that could activate spindle pole formation defects, affecting the cellular processes that C14orf106 is a part of. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $31.00 $65.00 | 6 | |
Inhibitor of the mitotic kinesin Eg5, which could activate spindle assembly defects, influencing C14orf106 function. | ||||||