C11orf56 Inhibitors

The FHF complex subunit HOOK interacting protein 1B, commonly referred to as HIP1B, is a component of the intracellular trafficking machinery. HIP1B is a member of the HOOK family of proteins that are characterized by their coiled-coil domains and a conserved Hook domain, which are essential for their role in endocytic trafficking and the maintenance of organelle morphology.HIP1B interacts with members of the FHF (FGFR1OP/FOP, HOOK, and FTS/HIP1R) complex, which is involved in the transport of vesicles between the Golgi apparatus and the endosomal system. This process is critical for the sorting and delivery of proteins and lipids throughout the cell, which is essential for maintaining cellular function and homeostasis. The FHF complex ensures that cargo is correctly directed to its destination, playing a pivotal role in vesicle tethering, docking, and fusion events.

The interactions HIP1B engages in are facilitated by its binding to microtubules and clathrin, a protein that forms the coat of vesicles budding from membranes. HIP1B's ability to associate with these structures suggests that it acts as a scaffold, organizing components of the trafficking machinery and stabilizing the cytoskeleton. This scaffolding is crucial for the precise control of vesicle formation, movement, and the spatial organization of endocytic processes.Mutations or dysregulation of HIP1B can disrupt normal trafficking and have been implicated in various pathological conditions, including neurodegeneration. Its role in endocytosis and vesicular trafficking also suggests a potential involvement in receptor internalization and signaling pathways.Overall, HIP1B is an essential protein for the proper functioning of intracellular transport systems, with its dysfunction possibly leading to a cascade of cellular irregularities contributing to disease.