C11orf53 Activators
C11orf53 engage in a cascade of intracellular events to modulate the protein's activity, primarily through the process of phosphorylation. Forskolin operates by stimulating adenylyl cyclase, which leads to an upsurge in cyclic AMP levels. This increment in cAMP can activate protein kinase A, which, if C11orf53 is a substrate, would lead to its phosphorylation and subsequent activation. Similarly, IBMX functions as a phosphodiesterase inhibitor, sustaining elevated levels of cAMP and indirectly contributing to the activation of protein kinase A, which may target C11orf53 for activation. In parallel, PMA is an activator of protein kinase C, a kinase that partakes in phosphorylating specific proteins, and C11orf53 may be among those affected by this pathway.
Ionomycin acts as a calcium ionophore, increasing intracellular calcium concentrations that trigger calmodulin-dependent kinase, which may phosphorylate C11orf53 if it is among its substrates. Anisomycin, on the other hand, inhibits protein synthesis but also activates stress-activated protein kinases such as JNK, which can phosphorylate target proteins, including potentially C11orf53. Okadaic Acid and Calyculin A disrupt protein phosphatase activity, leading to a net increase in protein phosphorylation, which can result in the activation of C11orf53 if it is usually regulated through dephosphorylation. A23187, similar to Ionomycin, raises intracellular calcium levels, possibly resulting in the activation of C11orf53 via calmodulin-dependent kinase pathways. Epidermal Growth Factor, by binding to its receptor, initiates a signaling cascade involving the MAPK/ERK pathway, which can culminate in the phosphorylation of C11orf53. Insulin elicits a response through its receptor, triggering the PI3K/Akt signaling pathway, which might phosphorylate and activate C11orf53. Bradykinin engages its receptor, initiating a sequence that increases PKC activity, which in turn might phosphorylate C11orf53. Lastly, Hydrogen Peroxide, as a reactive molecule, can activate kinases that may phosphorylate C11orf53, altering its activity state.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Isobutylmethylxanthine (IBMX) inhibits phosphodiesterases, preventing the breakdown of cAMP. Elevated cAMP levels can result in PKA activation, which could directly activate C11orf53 through phosphorylation if C11orf53 is a PKA substrate. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC). Activated PKC can phosphorylate target proteins, which could include C11orf53 if it is susceptible to PKC-mediated phosphorylation, leading to its activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore which increases intracellular calcium levels that can activate calmodulin-dependent kinase (CaMK). CaMK could then activate C11orf53 by phosphorylation if C11orf53 is a CaMK substrate. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that activates stress-activated protein kinases (SAPKs), including JNK. Activated JNK could potentially phosphorylate and activate C11orf53, if it is a target for JNK. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels of proteins. If C11orf53 is regulated by dephosphorylation, inhibition of these phosphatases could result in its activation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore like Ionomycin and can also lead to the activation of CaMK through increased intracellular calcium. If C11orf53 is a CaMK substrate, this could lead to its activation via phosphorylation. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin activates the insulin receptor, leading to activation of the PI3K/Akt signaling pathway. Akt can phosphorylate various proteins; if C11orf53 is an Akt substrate, this could result in its activation. | ||||||
Bradykinin | 58-82-2 | sc-507311 | 5 mg | $110.00 | ||
Bradykinin activates its receptor, leading to the activation of PLC, which in turn increases DAG and IP3 levels. This can activate PKC, and subsequently, if C11orf53 is a PKC substrate, it could be activated via phosphorylation. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Calyculin A is another inhibitor of protein phosphatases, similar to Okadaic Acid. If C11orf53 activation is controlled by phosphorylation state, inhibition of phosphatases could lead to its activation. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Hydrogen Peroxide is a reactive oxygen species that can act as a signaling molecule. It can activate various kinases through oxidative mechanisms. If C11orf53 activity is regulated by such kinases, hydrogen peroxide could lead to its activation | ||||||