c-Maf Inhibitors
c-Maf Inhibitors target and modulate the activity of the c-Maf protein, a transcription factor belonging to the Maf family. Transcription factors are pivotal in regulating gene expression by binding to specific DNA sequences and influencing the transcription of target genes. Structurally, c-Maf contains a basic leucine zipper (bZIP) domain, crucial for its dimerization and DNA-binding capabilities, allowing it to interact with DNA in a sequence-specific manner and activate or repress the transcription of target genes.
The functions of c-Maf are diverse and context-dependent, making it a central player in the regulation of gene expression in various cellular processes. c-Maf is involved in the differentiation and function of several cell types, including B cells, T cells, and plasma cells, where it plays a critical role in immune responses and antibody production. Additionally, c-Maf has been implicated in the development and maintenance of various tissues and organs, such as the lens of the eye and the pancreas, where it regulates tissue-specific gene expression. Furthermore, c-Maf is associated with cancer, as its dysregulation can lead to uncontrolled cell growth and tumorigenesis. c-Maf Inhibitors are designed to interfere with the DNA-binding activity, dimerization, or other functions of c-Maf, influencing gene expression and cellular processes. The study of c-Maf Inhibitors provides valuable insights into transcriptional regulation and the role of c-Maf in various physiological and pathological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Histone deacetylase inhibitor that can alter chromatin structure and gene expression, potentially leading to decreased c-Maf (Maf) expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This DNA methyltransferase inhibitor changes DNA methylation patterns, directly impacting the transcriptional regulation of c-Maf. By altering methylation at the c-Maf gene promoter, 5-Azacytidine can reduce its expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
As an HDAC inhibitor, Suberoylanilide Hydroxamic Acid changes the chromatin structure, specifically leading to increased histone acetylation that can repress the transcription of c-Maf, thereby reducing its expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
This mTOR inhibitor affects protein synthesis pathways, which are crucial for c-Maf translation. Rapamycin can lead to decreased c-Maf protein levels by inhibiting the translation process essential for c-Maf production. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2′-Deoxycytidine inhibits DNA methyltransferase, affecting the DNA methylation status of the c-Maf gene. This alteration can lead to reduced transcription and subsequent expression of c-Maf. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 inhibits BET bromodomain proteins, which are involved in the regulation of gene expression, including c-Maf. By inhibiting these proteins, JQ1 can decrease the transcriptional activity of c-Maf. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $196.00 | 9 | |
Panobinostat is an HDAC inhibitor that leads to alterations in chromatin structure, potentially downregulating c-Maf transcription by changing the acetylation status of histones associated with the c-Maf gene. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Proteasome inhibitor, potentially affecting c-Maf stability and expression by altering protein degradation pathways. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Inhibits ribonucleotide reductase, potentially reducing DNA synthesis and indirectly affecting c-Maf expression. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Causes DNA cross-linking and damage, potentially reducing c-Maf expression as a result of impaired transcription. | ||||||