C/EBP ε Inhibitors
C/EBP ε inhibitors belong to a class of chemical compounds that modulate the activity of CCAAT/enhancer-binding protein epsilon (C/EBP ε), a transcription factor primarily involved in regulating gene expression during cell differentiation, particularly in myeloid cells. C/EBP ε plays a crucial role in the transcriptional activation of genes necessary for the development and function of granulocytes, macrophages, and other immune-related cells. By inhibiting this transcription factor, C/EBP ε inhibitors disrupt its ability to bind to specific DNA sequences and initiate the transcription process. This inhibition affects the downstream regulation of various genes involved in cell growth, differentiation, and other key cellular processes, leading to changes in cell behavior and function.
The inhibitors are designed to specifically target the functional domains of C/EBP ε, such as the leucine zipper or DNA-binding domain, preventing the protein from dimerizing or binding to its cognate DNA sequences. Structural studies on these inhibitors reveal interactions with the key motifs of the transcription factor, allowing precise disruption of its activity without broadly affecting other members of the C/EBP family. Researchers often use C/EBP ε inhibitors as tools to investigate the molecular mechanisms that govern transcription factor function and their impact on cellular differentiation pathways. Understanding the nuances of C/EBP ε inhibition helps in elucidating the broader regulatory networks controlling immune cell development and gene expression patterns in various biological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
H-89 is a potent inhibitor of protein kinase A (PKA), which can prevent the phosphorylation of transcription factors that are potentially involved in the upregulation of C/EBP ε. | ||||||
GW 9662 | 22978-25-2 | sc-202641 | 5 mg | $70.00 | 30 | |
GW9662 is a selective PPARγ antagonist that can block the transcriptional activity of PPARγ, possibly leading to decreased expression of genes regulated by this receptor, including C/EBP ε. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA is a histone deacetylase inhibitor that, despite its general role in enhancing transcription, can lead to the specific repression of some genes, potentially including those encoding for C/EBP ε. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a selective inhibitor of MEK, which acts upstream of the ERK pathway. By inhibiting this pathway, the transcriptional activation of genes dependent on this route, possibly including C/EBP ε, can be reduced. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which is involved in cell growth and proliferation. Through this inhibition, it can lead to decreased protein synthesis and potentially lower expression of transcription factors such as C/EBP ε. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a potent inhibitor of the PI3K/Akt pathway, which can regulate various cellular processes including transcription. Inhibition of this pathway may lead to reduced activity or expression of C/EBP ε. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Flavopiridol is a cyclin-dependent kinase inhibitor that can halt cell cycle progression and influence transcription factor activity, potentially leading to decreased C/EBP ε expression. | ||||||
Wogonin, S. baicalensis | 632-85-9 | sc-203313 | 10 mg | $200.00 | 8 | |
Wogonin can inhibit the nuclear factor kappa B (NF-κB) signaling, which may result in the reduced expression of various genes, including potentially those related to C/EBP ε. | ||||||
Sulindac | 38194-50-2 | sc-202823 sc-202823A sc-202823B | 1 g 5 g 10 g | $32.00 $86.00 $150.00 | 3 | |
Sulindac can influence PPARγ and Wnt signaling pathways, potentially leading to decreased expression of genes under their control, which may include C/EBP ε. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
AG490 is a tyrosine kinase inhibitor, notably of JAK2, which may impact the JAK/STAT signaling pathway and potentially downregulate the transcriptional activity or expression of C/EBP ε. | ||||||