C/EBP α Activators
The chemical class of C/EBP α Activators involves a broad array of compounds that can influence the activity of CCAAT enhancer binding protein alpha (C/EBP α) either directly or indirectly. Forskolin and IBMX focus on elevating cellular cAMP levels, thereby activating Protein Kinase A (PKA). PKA can phosphorylate C/EBP α, which enhances its transcriptional activity. Rosiglitazone, a PPARγ agonist, activates C/EBP α through a cross-talk mechanism between the PPARγ and C/EBP α pathways. 8-Br-cAMP, a synthetic analog of cAMP, activates PKA and subsequently influences C/EBP α activation. MG132 is a proteasome inhibitor that sustains C/EBP α levels by preventing its degradation. Similarly, LY294002 inhibits PI3K to modulate C/EBP α by blocking its negative regulatory pathways.
Another subset of chemicals acts indirectly but effectively on C/EBP α. AICAR and A-769662 are AMPK activators, known to promote energy stress signaling, thereby enhancing C/EBP α transcriptional activity. Wnt-3a and Lithium Chloride manipulate the Wnt signaling pathway to influence C/EBP α activity indirectly through β-catenin. Indirubin inhibits GSK3β and, like Lithium Chloride, activates the Wnt/β-catenin signaling pathway, thereby promoting C/EBP α activity. Rapamycin inhibits mTOR and affects C/EBP α positively by attenuating pathways that would otherwise negatively regulate this transcription factor.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Elevates cAMP levels, thereby activating PKA, which can phosphorylate C/EBP α, enhancing its transcriptional activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Inhibits cAMP phosphodiesterase, increasing cAMP levels and leading to PKA activation and subsequently C/EBP α activation. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
PPARγ agonist, activates C/EBP α through cross-talk between PPARγ and C/EBP α pathways. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
cAMP analog that directly increases PKA activity, thereby can lead to phosphorylation and activation of C/EBP α. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Proteasome inhibitor, prevents the degradation of C/EBP α, leading to increased levels and activity. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AMPK activator, promotes energy stress signaling that can lead to increased C/EBP α transcriptional activity. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
Activates AMPK and indirectly influences C/EBP α activity through changes in energy balance and downstream signaling. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits GSK3β and activates Wnt/β-catenin signaling pathway, which can positively influence C/EBP α activity. | ||||||
Indirubin | 479-41-4 | sc-201531 sc-201531A | 5 mg 25 mg | $114.00 $525.00 | 4 | |
GSK3β inhibitor that activates Wnt/β-catenin signaling and can lead to increased C/EBP α activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
mTOR inhibitor, positively influences C/EBP α by attenuating pathways that can negatively regulate it. | ||||||