BTBD12 Activators
BTBD12 Activators are specific chemical compounds that directly or indirectly enhance the functional activity of BTBD12, a protein involved in the repair of DNA double-strand breaks. These compounds include Rucaparib, both of which are PARP inhibitors that increase the number of DNA double-strand breaks, thus enhancing the activity of BTBD12 which is involved in their repair. Other BTBD12 activators are DNA damaging agents like Mitomycin C, Etoposide, Cisplatin, and Bleomycin, which induce DNA breaks, consequently enhancing the functional activity of BTBD12 involved in their repair.
Additionally, BTBD12 activators include Hydroxyurea, a ribonucleotide reductase inhibitor that causes DNA breaks by depleting deoxyribonucleotides and stalling replication forks. Similarly, Camptothecin, Doxorubicin, and Irinotecan, which are inhibitors of topoisomerases I and II, stabilize the complexes between topoisomerases and DNA, leading to DNA breaks and subsequently enhancing the activity of BTBD12. 5-Fluorouracil and Gemcitabine, both of which are nucleoside analogs, also cause DNA breaks, leading to an enhancement of the functional activity of BTBD12. These compounds either directly cause DNA double-strand breaks or create conditions that lead to such breaks, thus creating a need for the repair mechanisms in which BTBD12 is involved. This subsequently leads to an increase in the functional activity of BTBD12, making these compounds effective activators of the protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rucaparib | 283173-50-2 | sc-507419 | 5 mg | $150.00 | ||
Rucaparib is another PARP inhibitor. Similarly to Olaparib, it leads to an increase in double-strand DNA breaks, which enhances the functional activity of BTBD12 as it is involved in their repair. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
Mitomycin C is a DNA crosslinking agent. It induces interstrand DNA crosslinks, which are processed into double-strand breaks. BTBD12 is involved in the repair of these breaks, leading to its functional activation. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide is a topoisomerase II inhibitor. It stabilizes the complex between topoisomerase II and DNA, leading to DNA breaks. BTBD12, involved in the repair of these breaks, hence sees its functional activity enhanced. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin forms DNA adducts that distort the DNA helix. This distortion can lead to double-strand breaks, enhancing the functional activity of BTBD12, which is involved in their repair. | ||||||
Bleomycin Sulfate | 9041-93-4 | sc-200134 sc-200134A sc-200134B sc-200134C | 10 mg 50 mg 100 mg 500 mg | $206.00 $612.00 $1020.00 $2856.00 | 38 | |
Bleomycin causes DNA strand breaks. This enhances the functional activity of BTBD12, which is involved in the repair of these breaks. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea is a ribonucleotide reductase inhibitor. It leads to depletion of deoxyribonucleotides and stalling of replication forks, which can result in DNA breaks. BTBD12, being involved in the repair of these breaks, sees its functional activity enhanced. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin is a topoisomerase I inhibitor. It stabilizes the complex between topoisomerase I and DNA, leading to DNA breaks. BTBD12, involved in the repair of these breaks, has its functional activity enhanced. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin intercalates into DNA and inhibits topoisomerase II, causing DNA breaks. BTBD12, involved in the repair of these breaks, has its functional activity enhanced. | ||||||
(+)-Irinotecan | 97682-44-5 | sc-269253 | 10 mg | $61.00 | 1 | |
Irinotecan is a topoisomerase I inhibitor. It stabilizes the complex between topoisomerase I and DNA, leading to DNA breaks. BTBD12, involved in the repair of these breaks, sees its functional activity enhanced. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
5-Fluorouracil is metabolized to fluorodeoxyuridine monophosphate, which inhibits thymidylate synthase, leading to depletion of deoxythymidine triphosphate and causing DNA breaks. BTBD12, involved in the repair of these breaks, has its functional activity enhanced. | ||||||