Chemical inhibitors of BST-1 can act through various mechanisms to impede the protein's functional activity, primarily targeting its role as a NAD glycohydrolase and ADP-ribosyl cyclase. Piceatannol and Apigenin are two such inhibitors that can inhibit BST-1 by reducing the availability of NAD+, which is an essential substrate for BST-1's enzymatic functions. Piceatannol achieves this by inhibiting the activity of CD38, a protein structurally related to BST-1 and involved in NAD+ metabolism. Apigenin, known for its CD38 inhibition, may similarly affect BST-1, given their functional parallels. Nicotinamide, serving as a non-competitive inhibitor, can occupy the NAD+ binding site or disrupt the catalytic activity of BST-1, while Flavopiridol, with its broad kinase inhibition properties, can also inhibit BST-1 through similar mechanisms.
Other chemicals can exert their inhibitory effects on BST-1 by influencing the cellular levels of NAD+ or interfering with BST-1's ability to interact with its substrate. FK866, a potent inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), can reduce NAD+ levels in cells, thus indirectly inhibiting the activity of BST-1 by substrate deprivation. Cladribine, although primarily used to disrupt nucleotide synthesis, can also affect BST-1 activity by altering NAD+ availability or through structural mimicry. Zinc, in excess, can inhibit BST-1 by binding to the enzyme and interfering with its normal function. Gallotannin, a known inhibitor of other ADP-ribosyl cyclases, can bind to the active site of BST-1, thus inhibiting its enzymatic action on NAD+. Kuromanin chloride, by inhibiting CD38, suggests a possible route to BST-1 inhibition due to the shared NAD glycohydrolase activity between the two proteins.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $51.00 $71.00 $199.00 | 11 | |
Inhibits the activity of CD38, a NADase, which is structurally related to BST-1. By inhibiting CD38, Piceatannol may reduce the availability of NAD+ required for BST-1 function, as BST-1 is a NAD glycohydrolase and ADP-ribosyl cyclase. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Known to inhibit CD38, and by similar mechanisms, could inhibit BST-1, which shares functional similarities as a NAD glycohydrolase and ADP-ribosyl cyclase. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
A non-competitive inhibitor of various sirtuins and ADP-ribosyltransferases, which could also inhibit BST-1 by occupying the NAD+ binding site or interfering with its catalytic activity as BST-1 has ADP-ribosyl cyclase activity. | ||||||
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $317.00 | ||
As a broad kinase inhibitor, Flavopiridol can inhibit CD38; similarly, it could inhibit BST-1, considering their functional similarities in NAD+ metabolism. | ||||||
Kuromanin chloride | 7084-24-4 | sc-235457 | 1 mg | $219.00 | 1 | |
Inhibits CD38, which could suggest functional inhibition of BST-1 due to structural and functional similarities, particularly in NAD glycohydrolase activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Excessive zinc can inhibit various NAD+/NADH utilizing enzymes, potentially inhibiting BST-1 due to its role in NAD+ metabolism. | ||||||
2-Chloro-2′-deoxyadenosine | 4291-63-8 | sc-202399 | 10 mg | $144.00 | 1 | |
While primarily targeting nucleotide synthesis pathways, Cladribine could potentially influence BST-1 activity by altering NAD+ levels or mimicking its structure, thereby inhibiting its enzymatic activity. | ||||||
Gallotannin | 1401-55-4 | sc-202619 sc-202619A sc-202619B sc-202619C sc-202619D sc-202619E sc-202619F | 1 g 10 g 100 g 250 g 1 kg 2.5 kg 5 kg | $26.00 $37.00 $67.00 $78.00 $234.00 $536.00 $983.00 | 12 | |
Known to inhibit other ADP-ribosyl cyclases, Gallotannin could inhibit BST-1 by binding to its active site or interfering with its catalytic action on NAD+. | ||||||
FK-866 | 658084-64-1 | sc-205325 sc-205325A | 5 mg 10 mg | $143.00 $250.00 | 12 | |
As a potent inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), FK866 could lower NAD+ levels, thereby inhibiting BST-1's NAD glycohydrolase and ADP-ribosyl cyclase activities by reducing the availability of its primary substrate, NAD+. | ||||||