BST-1 Activators
BST-1 activators encompass a range of chemical entities that enhance the functional activity of BST-1 through various mechanistic pathways. Phosphatidylinositol (3,4,5)-trisphosphate (PIP3), with its unique ability to serve as a docking site, significantly contributes to the recruitment and activation of BST-1 at the plasma membrane. This process is critical for BST-1 mediated signaling, particularly within immune cells, where signaling specificity and localization are essential for function. On the other hand, Ionomycin acts as a calcium ionophore that increases the intracellular concentration of calcium, a key second messenger in cellular signaling. This elevation in calcium levels can activate signaling cascades that involve BST-1. Similarly, Thapsigargin, by inhibiting the SERCA pump, leads to increased cytosolic calcium concentration, potentially enhancing the activity of BST-1 through calcium-dependent mechanisms integral to immune cell function. Furthermore, Forskolin directly targets adenylate cyclase, escalating cAMP levels and activating protein kinase A (PKA), which may then phosphorylate proteins within the signaling pathways BST-1 is part of, thus indirectly modulating BST-1 activity.
Indirect BST-1 activators involve a diverse range of molecules that affect BST-1 activity through secondary signaling events. Lysophosphatidic acid (LPA) and Sphingosine-1-phosphate (S1P) interact with G protein-coupled receptors, which activate downstream signaling involving RhoA, a molecule that influences cytoskeletal reorganization and cellular signaling cascades that can indirectly activate BST-1. Prostaglandin E2 (PGE2) and U46619, through their interaction with different G protein-coupled receptors, lead to the production of secondary messengers like cAMP or the activation of protein kinase C (PKC), both of which are involved in pathways that can enhance BST-1's functional activity. Similarly, Adenosine 5'-triphosphate (ATP) acts as a ligand for purinergic receptors, which can activate signaling pathways involving calcium fluxes and downstream kinases that modulate the activity of BST-1. Lastly, Phorbol 12-myristate 13-acetate (PMA) and W-7 modulate BST-1 activity through their effects on PKC and calcium-calmodulin-dependent signaling pathways, respectively, underscoring the intricate network of signaling routes that can influence BST-1 activity.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $96.00 $334.00 | 50 | |
LPA interacts with G protein-coupled receptors, which can activate downstream RhoA signaling. BST-1, being involved in signaling pathways related to cell migration and immune system function, can be indirectly activated due to LPA-induced cytoskeletal reorganization and cellular signaling cascades. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P engages with its own set of G protein-coupled receptors, which can initiate signaling pathways involving RhoA. BST-1, through its role in these pathways, can be indirectly activated by the changes in cellular dynamics and signaling that result from S1P interaction with its receptors, potentially enhancing BST-1's activity in immune response regulation. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
PGE2 binds to its E-prostanoid receptors, which are G protein-coupled receptors, leading to activation of adenylate cyclase and production of cAMP. This cascade can result in the activation of protein kinase A (PKA), which may phosphorylate and activate proteins within the same signaling pathways as BST-1, indirectly enhancing BST-1's functional activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylate cyclase, increasing levels of cAMP and activating PKA. PKA can phosphorylate various proteins involved in the immune response signaling pathways where BST-1 operates, potentially enhancing the functional activity of BST-1 indirectly through these pathways. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration. An elevation in calcium can activate signaling pathways that involve BST-1, such as those linked to the function of immune cells, thus potentially enhancing the activity of BST-1 indirectly by modulating calcium-dependent signaling processes. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $32.00 $75.00 $118.00 | 14 | |
FTY720 is a sphingosine-1-phosphate receptor modulator that can indirectly lead to the activation of signaling pathways relevant to BST-1's role in immune response. By altering S1P receptor activity, FTY720 modulates cellular responses and trafficking, which may enhance BST-1 activity as part of the immune system's signaling network. | ||||||
U-46619 | 56985-40-1 | sc-201242 sc-201242A | 1 mg 10 mg | $240.00 $1275.00 | 40 | |
U46619 mimics the action of thromboxane A2 by activating thromboxane/prostaglandin receptors. This activation can lead to increased intracellular calcium levels and activation of protein kinase C (PKC), which are part of signaling pathways involving BST-1. Therefore, U46619 can indirectly enhance BST-1 activity through its effect on calcium and PKC signaling. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor leading to increased cytosolic calcium concentration. Elevated calcium levels can activate numerous signaling pathways, including those in which BST-1 operates. This can indirectly enhance BST-1 activity through calcium-dependent mechanisms integral to BST-1's function in immune cells. | ||||||
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $38.00 $74.00 | 9 | |
ATP acts as a ligand for purinergic receptors, which can activate signaling pathways involving calcium fluxes and downstream kinases. These kinases may modulate the activity of proteins within BST-1 related pathways, potentially enhancing BST-1's function in processes such as immune cell activation and signaling. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which plays a role in various signaling pathways,including those related to immune response and cell activation. As BST-1 is involved in immune cell signaling, PMA-induced PKC activation may lead to enhanced activity of BST-1 through PKC-mediated signaling pathways. | ||||||