BRAT1 Inhibitors
BRAT1 inhibitors are a class of compounds that reduce or block the activity of the BRAT1 (BRCA1-associated ATM activator 1) protein, encoded by the BRAT1 gene on chromosome 10. The BRAT1 protein is involved in vital cellular processes, including the DNA damage response, regulation of the cell cycle, and apoptosis. It interacts with other proteins such as ATM (Ataxia-telangiectasia mutated) and BRCA1, which are key players in the DNA repair and genomic stability pathways. The proper functioning of BRAT1 ensures that cells can effectively respond to DNA damage, making it a crucial component of the cellular response to genotoxic stress. The BRAT1 gene is widely expressed across different tissues, with particularly high expression in cells undergoing significant replication or stress, such as neurons.
BRAT1 inhibitors work by reducing the activity of this protein, enabling researchers to dissect its biological roles and contributions to cellular signaling. These inhibitors can vary chemically, ranging from small molecules to more complex entities designed to interfere with BRAT1's interactions with its protein partners. By studying the effects of BRAT1 inhibition, researchers gain insights into the pathways it regulates, such as its involvement in the DNA damage response or its role in maintaining cellular homeostasis. The exploration of structure-activity relationships in BRAT1 inhibitors helps to determine how different chemical modifications can affect their binding affinity and specificity for the BRAT1 protein. These investigations contribute to a broader understanding of BRAT1's function in cellular systems and its regulatory networks.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. BRAT1, being a part of DNA damage response, may have kinase-dependent activation. By inhibiting kinase activity, Staurosporine could reduce BRAT1-mediated DNA repair processes. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of PI3Ks. BRAT1 is thought to be involved in the PI3K/Akt pathway, and inhibition of this pathway by LY294002 may lead to decreased activation of BRAT1. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor. It can indirectly decrease BRAT1 activity by inhibiting the PI3K/Akt pathway, which is crucial for DNA damage response and cell survival. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a downstream effector of PI3K/Akt pathway. Since BRAT1 is associated with the PI3K/Akt pathway, inhibition of mTOR by Rapamycin could decrease BRAT1 activity. | ||||||
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $108.00 | 28 | |
KU-55933 is an ATM kinase inhibitor. BRAT1 is known to interact with ATM for the proper DNA damage response. Inhibition of ATM could thus impair BRAT1 function. | ||||||
NU 7441 | 503468-95-9 | sc-208107 | 5 mg | $350.00 | 10 | |
NU7441 is a potent DNA-PKcs inhibitor. BRAT1's role in the DNA damage response might be partially modulated by DNA-PKcs, and its inhibition could affect BRAT1's functionality. | ||||||
AZD7762 | 860352-01-8 | sc-364423 | 2 mg | $107.00 | ||
AZD7762 is a CHK1 inhibitor. CHK1 is essential for cell cycle arrest during DNA damage, an event where BRAT1 is implicated. Inhibition of CHK1 could therefore reduce the functional activity of BRAT1. | ||||||
PD 0332991 Isethionate | 827022-33-3 | sc-478943 | 1 mg | $300.00 | ||
PD0332991 is a CDK4/6 inhibitor. BRAT1 may be involved in cell cycle regulation via CDK4/6; thus, inhibiting these kinases could lead to decreased BRAT1 activity. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
Olaparib is a PARP inhibitor used in DNA repair. BRAT1 is associated with the homologous recombination pathway; by inhibiting PARP, Olaparib could indirectly impair BRAT1 function. | ||||||
Veliparib | 912444-00-9 | sc-394457A sc-394457 sc-394457B | 5 mg 10 mg 50 mg | $178.00 $270.00 $712.00 | 3 | |
Veliparib is another PARP inhibitor. It can potentially affect BRAT1 activity by impairing the DNA repair mechanisms in which BRAT1 is involved. | ||||||