BPGM Activators
BPGM activators are chemical agents that promote the enzymatic activity of bisphosphoglycerate mutase (BPGM), a key regulatory enzyme in erythrocytes that catalyzes the conversion of 1,3-bisphosphoglycerate (1,3-BPG) to 2,3-bisphosphoglycerate (2,3-BPG). The generation of 2,3-BPG is a crucial step in the regulation of hemoglobin's oxygen-binding affinity, which in turn influences oxygen release to tissues. Activators of BPGM can enhance the enzyme's activity, leading to increased production of 2,3-BPG.
Direct activators of BPGM might bind to the enzyme and induce a conformational change that increases its catalytic efficiency, either by facilitating the binding of the substrate to the active site or by stabilizing the transition state of the reaction. These compounds often interact with regions of the enzyme that are distinct from the substrate binding site, allosterically modifying the enzyme's structure to enhance its natural activity. Indirect activators may work by upregulating the expression of the BPGM gene, thereby increasing the amount of enzyme produced within the cell. Alternatively, they might prolong the half-life of the BPGM protein by inhibiting its degradation pathways or by stabilizing its structure through post-translational modifications. Indirect activators could also influence other cellular factors that interact with BPGM, enhancing its activity without directly binding to the enzyme itself.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-Fructose 1,6-bisphosphate sodium salt | 488-69-7 | sc-484714 | 50 g | $298.00 | ||
Fructose 1,6-bisphosphate is an intermediate in the glycolytic pathway. It can increase the quantity of 1,3-bisphosphoglycerate, the substrate for BPGM, thus potentially enhancing its activity. | ||||||
D(+)Glucose, Anhydrous | 50-99-7 | sc-211203 sc-211203B sc-211203A | 250 g 5 kg 1 kg | $37.00 $194.00 $64.00 | 5 | |
Glucose initiates the glycolytic pathway, leading to the production of 1,3-bisphosphoglycerate. The increase in 1,3-bisphosphoglycerate provides more substrate for BPGM, potentially enhancing its activity. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $39.00 $45.00 $98.00 | 26 | |
Sodium Fluoride inhibits enolase in the glycolytic pathway, potentially increasing the concentration of 2-phosphoglycerate, the substrate for BPGM, and thus enhancing its activity. | ||||||
Pyruvic acid | 127-17-3 | sc-208191 sc-208191A | 25 g 100 g | $40.00 $94.00 | ||
Pyruvate is the end product of glycolysis. Increasing pyruvate can drive the glycolytic pathway, potentially increasing the amount of 1,3-bisphosphoglycerate, the substrate for BPGM, and enhancing its activity. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NAD+ is involved in the glycolytic pathway, and its presence can stimulate the production of 1,3-bisphosphoglycerate, the substrate for BPGM, potentially enhancing its activity. | ||||||
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $38.00 $74.00 | 9 | |
ATP is used in the first step of the glycolytic pathway, which leads to the production of 1,3-bisphosphoglycerate. More ATP could potentially enhance the activity of BPGM by providing more substrate. | ||||||
Citric Acid, Anhydrous | 77-92-9 | sc-211113 sc-211113A sc-211113B sc-211113C sc-211113D | 500 g 1 kg 5 kg 10 kg 25 kg | $49.00 $108.00 $142.00 $243.00 $586.00 | 1 | |
Citrate inhibits phosphofructokinase, a regulatory enzyme in glycolysis, potentially increasing the availability of 1,3-bisphosphoglycerate, BPGM's substrate, and thus enhancing its activity. | ||||||
D-Galactose | 59-23-4 | sc-202564 | 100 g | $224.00 | 4 | |
Galactose is converted into glucose-1-phosphate, which can enter glycolysis, potentially increasing the availability of 1,3-bisphosphoglycerate, the substrate for BPGM, and thus enhancing its activity. | ||||||
Lactic acid | 50-21-5 | sc-215227 sc-215227A | 100 ml 500 ml | $100.00 $175.00 | 1 | |
Lactate can be converted back into pyruvate, driving the glycolytic pathway forward, potentially increasing the availability of 1,3-bisphosphoglycerate, the substrate for BPGM, and thus enhancing its activity. | ||||||