BPGM Antibody (C-4): sc-373819
- BPGM Antibody (C-4) is a mouse monoclonal IgG1 κ BPGM antibody, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 153-185 within an internal region of BPGM of human origin
- BPGM Antibody (C-4) is recommended for detection of BPGM of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including bovine
- Anti-BPGM Antibody (C-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for BPGM Antibody (C-4) for WB applications. These reagents are now offered in bundles with BPGM Antibody (C-4) (see ordering information below).
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BPGM Antibody (C-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects BPGM protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BPGM (C-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BPGM protein, or 2,3-bisphosphoglycerate mutase, consists of 259 amino acids and is a member of the phosphoglycerate mutase family, functioning primarily as a homodimer. BPGM plays a vital role in the regulation of hemoglobin′s oxygen affinity by catalyzing the conversion of 3-phospho-D-glyceroyl phosphate to 2,3-bisphospho-D-glycerate (2,3-BPG). This reaction modulates the concentration of 2,3-BPG within red blood cells, which is crucial for oxygen delivery to tissues. BPGM is encoded on human chromosome 7, a region associated with various genetic disorders, including Osteogenesis imperfecta and Williams-Beuren syndrome. Anti-BPGM antibody (C-4) helps researchers gain insights into BPGM′s function and implications in oxygen transport and related pathologies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
BPGM Antibody (C-4) References:
- Structural modeling of the human erythrocyte bisphosphoglycerate mutase. | Craescu, CT., et al. 1992. Biochimie. 74: 519-26. PMID: 1387804
- Crystal structure of human bisphosphoglycerate mutase. | Wang, Y., et al. 2004. J Biol Chem. 279: 39132-8. PMID: 15258155
- Seeing the process of histidine phosphorylation in human bisphosphoglycerate mutase. | Wang, Y., et al. 2006. J Biol Chem. 281: 39642-8. PMID: 17052986
- Molecular cloning of the human 2,3-bisphosphoglycerate mutase cDNA and revised amino acid sequence. | Cohen-Solal, M., et al. 1987. Biomed Biochim Acta. 46: S126-30. PMID: 3036106
- The complete amino acid sequence of human erythrocyte diphosphoglycerate mutase. | Haggarty, NW., et al. 1983. EMBO J. 2: 1213-20. PMID: 6313356
- The platelet-activating factor acetylhydrolase from human erythrocytes. Purification and properties. | Stafforini, DM., et al. 1993. J Biol Chem. 268: 3857-65. PMID: 8440681
- A study on the complexes between human erythrocyte enzymes participating in the conversions of 1,3-diphosphoglycerate. | Fokina, KV., et al. 1997. Arch Biochem Biophys. 345: 185-92. PMID: 9308888
- Human erythrocyte bisphosphoglycerate mutase: inactivation by glycation in vivo and in vitro. | Fujita, T., et al. 1998. J Biochem. 124: 1237-44. PMID: 9832630
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BPGM Antibody (C-4) | sc-373819 | 200 µg/ml | $316.00 | |||
BPGM Antibody (C-4): m-IgG Fc BP-HRP Bundle | sc-529577 | 200 µg Ab; 10 µg BP | $354.00 | |||
BPGM Antibody (C-4): m-IgGκ BP-HRP Bundle | sc-522515 | 200 µg Ab, 40 µg BP | $354.00 | |||
BPGM Antibody (C-4): m-IgG1 BP-HRP Bundle | sc-543592 | 200 µg Ab; 20 µg BP | $354.00 | |||
BPGM Antibody (C-4) AC | sc-373819 AC | 500 µg/ml, 25% agarose | $416.00 | |||
BPGM Antibody (C-4) HRP | sc-373819 HRP | 200 µg/ml | $316.00 | |||
BPGM Antibody (C-4) FITC | sc-373819 FITC | 200 µg/ml | $330.00 | |||
BPGM Antibody (C-4) PE | sc-373819 PE | 200 µg/ml | $343.00 | |||
BPGM Antibody (C-4) Alexa Fluor® 488 | sc-373819 AF488 | 200 µg/ml | $357.00 | |||
BPGM Antibody (C-4) Alexa Fluor® 546 | sc-373819 AF546 | 200 µg/ml | $357.00 | |||
BPGM Antibody (C-4) Alexa Fluor® 594 | sc-373819 AF594 | 200 µg/ml | $357.00 | |||
BPGM Antibody (C-4) Alexa Fluor® 647 | sc-373819 AF647 | 200 µg/ml | $357.00 | |||
BPGM Antibody (C-4) Alexa Fluor® 680 | sc-373819 AF680 | 200 µg/ml | $357.00 | |||
BPGM Antibody (C-4) Alexa Fluor® 790 | sc-373819 AF790 | 200 µg/ml | $357.00 | |||
BPGM (C-4) Neutralizing Peptide | sc-373819 P | 100 µg/0.5 ml | $68.00 |