BPAG1n3 inhibitors, also known as BPAG1n3 (BPAG1-nerve-specific 3 isoform) protein inhibitors, represent a class of chemical compounds designed to selectively target and modulate the activity of the BPAG1n3 protein. BPAG1n3 is a specific isoform of the BPAG1 (Bullous Pemphigoid Antigen 1) protein family, which plays a crucial role in maintaining the structural integrity of skin and nerve cells. These inhibitors are engineered to interfere with the function of BPAG1n3, thereby offering potential insights into the molecular mechanisms governing skin and neuronal biology.
The BPAG1n3 protein, primarily expressed in nerve cells, contributes to the stability and integrity of the axonal cytoskeleton by linking it to the extracellular matrix. BPAG1n3 inhibitors are designed to target specific regions or molecular interactions associated with this protein, aiming to disrupt its function or interactions with other cellular components. By selectively modulating BPAG1n3, researchers can investigate its role in various cellular processes, such as axonal transport, neuronal development, and synaptic plasticity. This class of inhibitors serves as valuable research tools for probing the intricate pathways and interactions that underlie the maintenance of neural structures and the functioning of the skin. It is important to note that the primary utility of BPAG1n3 inhibitors lies in advancing our fundamental understanding of cell biology and may have potential implications in various fields, although their specific applications in therapy or medicine are not within the scope of this description.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $26.00 $119.00 $213.00 | 27 | |
Inhibits the tyrosine kinase activity of Bcr-Abl, blocking its signaling cascade, which is essential for the growth and survival of cancer cells. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $63.00 $114.00 $218.00 $349.00 | 74 | |
Targets the epidermal growth factor receptor (EGFR), blocking the activation of downstream signaling pathways involved in cell proliferation. | ||||||
Erlotinib, Free Base | 183321-74-6 | sc-396113 sc-396113A sc-396113B sc-396113C sc-396113D | 500 mg 1 g 5 g 10 g 100 g | $87.00 $135.00 $293.00 $505.00 $3827.00 | 42 | |
Also inhibits EGFR, hindering the phosphorylation of tyrosine residues and the subsequent cell division and growth. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
Multi-kinase inhibitor that disrupts the Raf/MEK/ERK pathway and VEGFR/PDGFR signaling, reducing angiogenesis and tumor cell proliferation. | ||||||
Sunitinib Malate | 341031-54-7 | sc-220177 sc-220177A sc-220177B | 10 mg 100 mg 3 g | $197.00 $520.00 $1093.00 | 4 | |
Targets multiple receptor tyrosine kinases (RTKs) like VEGFR, PDGFR, and c-KIT, impeding tumor angiogenesis and cell survival. | ||||||
Lapatinib | 231277-92-2 | sc-353658 | 100 mg | $420.00 | 32 | |
Dual EGFR/HER2 inhibitor, blocking both receptors' kinase activities, which are often overexpressed in cancer cells. | ||||||
MDV3100 | 915087-33-1 | sc-364354 sc-364354A | 5 mg 50 mg | $245.00 $1051.00 | 7 | |
Acts as an androgen receptor (AR) antagonist, preventing AR translocation to the nucleus and inhibiting AR-mediated gene transcription in prostate cancer. | ||||||
Everolimus | 159351-69-6 | sc-218452 sc-218452A | 5 mg 50 mg | $131.00 $651.00 | 7 | |
mTOR inhibitor that interferes with the PI3K/Akt/mTOR pathway, impeding cell growth and proliferation. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
PARP inhibitor, disrupting DNA repair mechanisms in BRCA-mutated cancer cells, leading to genomic instability and cell death. | ||||||
Abiraterone | 154229-19-3 | sc-460288 | 10 mg | $276.00 | ||
Inhibits CYP17A1, an enzyme crucial for androgen biosynthesis, lowering androgen levels in prostate cancer. | ||||||