Bonzo Activators
Bonzo activators encompass a spectrum of chemical entities that enhance the functional activity of the Bonzo protein through intricate cellular signaling pathways. For instance, AMD3100 fortifies Bonzo's signaling by competitively inhibiting the CXCR4 receptor, which may shift chemotactic responses and ligand availability in favor of Bonzo. Prostaglandin E2, by binding to EP receptors, elevates intracellular cAMP, thus priming Bonzo for heightened responsiveness through cAMP-dependent protein kinase A (PKA) pathways. Sulforaphane triggers the Nrf2 pathway to bolster cellular defense mechanisms, thereby indirectly supporting Bonzo's optimal function in a less stressed cellular milieu. Forskolin, known to directly activate adenylyl cyclase, boosts cAMP levels and, consequently, Bonzo's G protein-coupled receptor signaling. Sphingosine-1-phosphate, through receptor-mediated actions, can synergize with Bonzo's role in cellular migration and interaction, potentially enhancing its activity.
In the realm of intracellular second messengers, Rolipram, by inhibiting PDE4, maintains cAMP within the cell, thereby amplifying Bonzo signaling. Ionomycin, introducing elevated intracellular calcium, indirectly activates Bonzo through the stimulation of calcium-dependent kinases. Bryostatin 1, a PKC activator, might enhance Bonzo's phosphorylation state, leading to improved receptor function. Anisomycin, through JNK pathway activation, and UTP, by engaging with P2Y receptors, both contribute to creating an environment conducive to Bonzo activation by modulating the surrounding signaling landscape. Isoproterenol, by stimulating beta-adrenergic receptors, elevates cAMP and indirectly potentiates Bonzo signaling. Lastly, A23187, by increasing calcium levels, could amplify Bonzo's activity by engaging calcium-dependent signaling pathways. Collectively, these compounds, through their distinct biochemical mechanisms, facilitate the enhancement of Bonzo's functional activity without directly altering its expression levels.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 engages multiple signaling pathways, including the EP2 and EP4 receptors, leading to increased cAMP levels. Elevated cAMP can enhance the functional activity of Bonzo through cross-talk and sensitization of the receptor, which is essential for its ligand-mediated signaling functions. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane is an activator of the Nrf2 pathway, which leads to the transcription of various cytoprotective genes. It can enhance Bonzo activity indirectly by upregulating cellular antioxidants and detoxifying enzymes, thus creating an intracellular environment that supports Bonzo's signaling efficiency. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, resulting in increased cAMP levels. This increase can promote Bonzo signaling by enhancing G protein-coupled receptor function, as cAMP is a second messenger in G protein-coupled receptor pathways such as the one Bonzo is part of. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P operates through its receptors to regulate a myriad of cellular processes, including migration and cell-cell interactions. By affecting the S1P receptor signaling, it may create a favorable environment for Bonzo activation as both receptors can be involved in similar cellular processes. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), which degrades cAMP. By inhibiting PDE4, Rolipram increases intracellular cAMP levels, thereby potentiating Bonzo receptor signaling through the protein kinase A (PKA) pathway. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore, which increases intracellular calcium levels, a second messenger in various signaling pathways. Elevated calcium can indirectly enhance Bonzo activity by stimulating calcium-dependent protein kinases that might phosphorylate and activate the receptor or its associated proteins. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $240.00 | 9 | |
Bryostatin 1 is a protein kinase C (PKC) activator. PKC enzymes can modulate the activity of G protein-coupled receptors like Bonzo, potentially enhancing its signaling capacity through phosphorylation events. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a JNK activator, and JNK signaling can modulate the activity of several receptors and cellular processes. Bonzo activity could be indirectly enhanced through the modulation of cellular environments by JNK pathway activation. | ||||||
Uridine-5′-triphosphate, Trisodium Salt | 19817-92-6 | sc-301964 sc-301964A | 50 mg 1 g | $86.00 $118.00 | 2 | |
UTP, through its action on P2Y receptors, can lead to the activation of PLCβ, increasing inositol trisphosphate (IP3) and diacylglycerol (DAG), and intracellular calcium. These secondary messengers may enhance Bonzo signaling indirectly by influencing the receptor's microenvironment. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic receptor agonist, which increases intracellular levels of cAMP through the activation of adenylyl cyclase. The increased cAMP levels may enhance the G protein-coupled receptor signaling of Bonzo. | ||||||