Bonzo Antibody (43F09): sc-73753

Bonzo Antibody (43F09) is a rat monoclonal IgG2b antibody that detects the Bonzo protein of mouse origin by flow cytometry (FCM). Anti-Bonzo antibody (43F09) is available as the non-conjugated format. Bonzo protein, also known as STRL33.3, is a member of the seven-transmembrane, G protein-coupled receptor family, which plays a crucial role in immune response and cell signaling. Specifically, Bonzo is involved in the entry of certain viruses, including simian immunodeficiency virus (SIV), HIV-2, and M-tropic HIV-1, into host cells, highlighting Bonzo′s importance in virology and immunology. Bonzo protein is predominantly expressed in lymphoid tissues, where Bonzo contributes to the regulation of immune cell trafficking and activation. Additionally, Bonzo′s interaction with CD4 and various chemokine receptors underscores Bonzo′s significance in the context of HIV research, as understanding these interactions can lead to insights into viral pathogenesis and potential therapeutic targets. Anti-Bonzo antibody (43F09) is an essential tool for researchers studying the mechanisms of viral entry and immune response in mouse models.

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Bonzo Antibody (43F09) References:

1. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor.  |  Feng, Y., et al. 1996. Science. 272: 872-7. PMID: 8629022
2. Identification of a major co-receptor for primary isolates of HIV-1.  |  Deng, H., et al. 1996. Nature. 381: 661-6. PMID: 8649511
3. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5.  |  Dragic, T., et al. 1996. Nature. 381: 667-73. PMID: 8649512
4. CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1.  |  Alkhatib, G., et al. 1996. Science. 272: 1955-8. PMID: 8658171
5. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.  |  Choe, H., et al. 1996. Cell. 85: 1135-48. PMID: 8674119
6. A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors.  |  Doranz, BJ., et al. 1996. Cell. 85: 1149-58. PMID: 8674120
7. A novel human gene encoding a G-protein-coupled receptor (GPR15) is located on chromosome 3.  |  Heiber, M., et al. 1996. Genomics. 32: 462-5. PMID: 8838812
8. Expression cloning of new receptors used by simian and human immunodeficiency viruses.  |  Deng, HK., et al. 1997. Nature. 388: 296-300. PMID: 9230441