BONO1 Activators
BONO1 Activators encompass a spectrum of chemical compounds that indirectly enhance the functional activity of BONO1 through distinct signaling cascades. Forskolin, Isoproterenol, Epinephrine, and Histamine all elevate intracellular cAMP levels, subsequently activating protein kinase A (PKA). Activated PKA is known to phosphorylate target proteins, which is one mechanism by which the activity of BONO1 could be enhanced. Similarly, IBMX and Rolipram, by inhibiting cAMP degradation, sustain PKA activation and prolong the potential for BONO1 phosphorylation and activation. The enhancement of BONO1 is also facilitated by the action of PMA, which activates protein kinase C (PKC) that could phosphorylate and increase BONO1 activity within its specific signaling pathways. Furthermore, L-Arginine contributes to BONO1 activation by increasing nitric oxide production, which activates guanylate cyclase, leading to increased cGMP levels and activation of protein kinase G (PKG). PKG, like PKA, could phosphorylate BONO1 and enhance its signaling functions.
Moreover, the functional activity of BONO1 is influenced by the modulation of the cGMP pathway by compounds such as Vardenafil, Sildenafil, and Zaprinast. These phosphodiesterase-5 inhibitors raise cGMP levels, leading to PKG activation, which can then phosphorylate and activate BONO1. Anisomycin, acting as a stress-activated protein kinase activator, can lead to the activation of JNK, which may further phosphorylateBONO1, thereby enhancing its role in stress response pathways. Collectively, these BONO1 Activators, through their target-specific actions on cellular signaling, are capable of facilitating the enhancement of BONO1 mediated functions, effectively amplifying its signaling capacity without necessitating the upregulation of its expression or direct activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly increases intracellular cAMP levels. Elevated cAMP activates PKA, which in turn can phosphorylate BONO1, leading to its enhanced activation and function in cellular signaling. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, which prevents cAMP degradation, thereby indirectly increasing the activity of BONO1 by maintaining elevated levels of cAMP for PKA activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC). PKC, in turn, can phosphorylate target proteins including BONO1 to enhance its function within cellular signaling pathways. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that leads to increased cAMP levels, subsequently activating PKA. PKA activation can lead to the phosphorylation and enhancement of BONO1 activity. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $30.00 $60.00 $215.00 $345.00 | 2 | |
L-Arginine is a substrate for nitric oxide synthase, which produces nitric oxide (NO). NO can activate guanylate cyclase, increasing cGMP levels and activating PKG. PKG can then phosphorylate BONO1, leading to its activation. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine, through its action on beta-adrenergic receptors, increases cAMP production leading to PKA activation. This cascade can enhance the function of BONO1 through phosphorylation. | ||||||
Vardenafil | 224785-90-4 | sc-362054 sc-362054A sc-362054B | 100 mg 1 g 50 g | $516.00 $720.00 $16326.00 | 7 | |
Vardenafil inhibits phosphodiesterase-5, leading to an increase in cGMP levels. The rise in cGMP levels can indirectly influence BONO1 activity through PKG-mediated phosphorylation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a potent activator of the stress-activated protein kinases such as JNK. JNK activation could phosphorylate BONO1, resulting in its functional activation within stress response pathways. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
Zaprinast inhibits phosphodiesterase-5, leading to an accumulation of cGMP and activation of PKG. PKG can then phosphorylate and enhance the activity of BONO1. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine, through its receptor H2, can increase cAMP levels, leading to PKA activation. PKA can then phosphorylate BONO1, enhancing its activity. | ||||||