BOB_GPR15 Activators
BOB, also known as GPR15 (G protein-coupled receptor 15), is a protein that in humans is encoded by the GPR15 gene. GPR15 is a member of the G protein-coupled receptor (GPCR) family, one of the largest families of proteins involved in signal transduction across cell membranes.GPR15 functions as a receptor for a chemokine called CCL5 (also known as RANTES). Upon binding to CCL5, GPR15 initiates signal transduction pathways that lead to various cellular responses, including cell migration and activation of immune responses.
GPR15 is expressed in several tissues, including immune cells like T cells. In these cells, GPR15 plays a crucial role in their homing to specific tissues. For example, it is involved in the recruitment of T cells to the colon, which is relevant in the context of inflammatory bowel disease (IBD) and colorectal cancer.Interestingly, GPR15 has also been identified as a co-receptor for certain strains of HIV-1, allowing the virus to enter and infect cells. This has implications for understanding the pathogenesis of HIV.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
INK 128 | 1224844-38-5 | sc-364511 sc-364511A | 5 mg 50 mg | $321.00 $1835.00 | ||
A kinesin spindle protein (KSP) inhibitor; influences cellular processes that can indirectly modulate GPR15 activity by disrupting microtubule dynamics. | ||||||
AZD7762 | 860352-01-8 | sc-364423 | 2 mg | $107.00 | ||
A checkpoint kinase inhibitor; indirectly affects GPR15 by modulating the DNA damage response pathway, influencing cell cycle regulation. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
An aurora kinase A inhibitor; disrupts cell division and proliferation pathways, potentially impacting GPR15 expression and function. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $151.00 $525.00 | 8 | |
A PLK1 inhibitor; modulates GPR15 function by interfering with mitotic processes and cell cycle progression. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
An Aurora kinase inhibitor; can indirectly affect GPR15 signaling by altering protein phosphorylation in cell division processes. | ||||||
BI6727 | 755038-65-4 | sc-364432 sc-364432A sc-364432B sc-364432C sc-364432D | 5 mg 50 mg 100 mg 500 mg 1 g | $150.00 $1050.00 $1665.00 $3329.00 $4382.00 | 1 | |
A PLK1 inhibitor, similar to BI-2536; influences GPR15 activity by modulating cell cycle and mitotic processes. | ||||||
TAK-733 | 1035555-63-5 | sc-364630 sc-364630A | 5 mg 10 mg | $340.00 $640.00 | 1 | |
A checkpoint kinase 2 inhibitor; impacts GPR15 indirectly by altering cell cycle checkpoints, particularly in response to DNA damage. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $251.00 $500.00 $547.00 | 16 | |
Another JAK inhibitor; can influence GPR15 activity indirectly through cytokine signaling pathway modulation. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $321.00 | ||
A CDK4/6 inhibitor; indirectly affects GPR15 activity by altering the cell cycle, particularly the G1-S phase transition. | ||||||
ABT-199 | 1257044-40-8 | sc-472284 sc-472284A sc-472284B sc-472284C sc-472284D | 1 mg 5 mg 10 mg 100 mg 3 g | $118.00 $337.00 $520.00 $832.00 $1632.00 | 10 | |
A BCL-2 inhibitor; influences apoptotic pathways, which can indirectly affect GPR15 signaling, especially where cell survival and apoptosis intersect with GPR15-related pathways. | ||||||