BMP-8B Inhibitors
BMP-8B inhibitors represent a class of chemical compounds that have garnered interest in the fields of molecular biology and pharmacology due to modulating specific cellular processes. BMP-8B, or Bone Morphogenetic Protein 8B, is a member of the transforming growth factor-beta (TGF-β) superfamily and plays a critical role in embryonic development, tissue homeostasis, and cellular differentiation. It functions as a signaling molecule involved in various cellular processes, including cell growth, differentiation, and apoptosis. BMP-8B inhibitors are designed to interact with the active site or binding domain of the BMP-8B protein, effectively inhibiting its function and influencing cellular processes dependent on BMP-8B-mediated signaling.
Structurally, BMP-8B inhibitors are engineered to selectively target the active site of BMP-8B, ensuring high specificity for this particular signaling molecule. By inhibiting BMP-8B, these compounds may disrupt its role in cellular processes, affecting various aspects of development and tissue maintenance. The study of BMP-8B inhibitors is of significant interest to researchers as it provides insights into the regulatory mechanisms governing essential cellular functions and their impact on embryogenesis, tissue regeneration, and cellular differentiation. This knowledge contributes to our understanding of basic cell biology and may have implications in various research areas, including developmental biology, tissue engineering, and regenerative medicine. However, further research is required to fully explore the extent of their applications and their impact on cellular physiology in the context of BMP-8B-mediated signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that may alter multiple signaling pathways, potentially reducing the expression of genes like BMP-8B. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542 is an inhibitor of the TGF-β receptor kinase that could indirectly downregulate BMP signaling and thus BMP-8B expression. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $96.00 $355.00 | 69 | |
Dorsomorphin inhibits BMP signaling by targeting the BMP type I receptors ALK2, ALK3, and ALK6, potentially affecting BMP-8B expression. | ||||||
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | 1062368-24-4 | sc-476297 | 5 mg | $240.00 | ||
LDN-193189 is a BMP receptor inhibitor that could, in turn, reduce BMP-8B expression by blocking its signaling. | ||||||
DMH-1 | 1206711-16-1 | sc-361171 sc-361171B sc-361171A sc-361171C | 10 mg 25 mg 50 mg 100 mg | $213.00 $318.00 $632.00 $1047.00 | 2 | |
DMH1 is a selective BMP receptor inhibitor, which could lead to a decrease in BMP-8B expression through signaling inhibition. | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $202.00 $811.00 | 16 | |
A-83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, which may indirectly affect BMP-8B expression levels. | ||||||
LDN-214117 | 1627503-67-6 | sc-507451 | 5 mg | $165.00 | ||
LDN-214117 is an ALK2 inhibitor that might downregulate BMP-8B expression through inhibition of BMP signaling pathways. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $96.00 $292.00 | 27 | |
IWP-2 is an inhibitor of Wnt production, which could indirectly affect BMP-8B expression due to crosstalk between the Wnt and BMP pathways. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 is a BET bromodomain inhibitor affecting gene expression, which could potentially downregulate BMP-8B transcription. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a ROCK inhibitor that could alter the actin cytoskeleton, possibly affecting BMP-8B expression indirectly. | ||||||