BIG1 Activators
BIG1 activators belong to a distinctive chemical class characterized by their ability to modulate the activity of the BIG1 protein. BIG1, or Brefeldin A-inhibited guanine nucleotide-exchange protein 1, is a crucial component in cellular processes related to membrane trafficking and vesicle transport within cells. These activators exert their influence on BIG1 by promoting its activation, thereby facilitating its role as a guanine nucleotide-exchange factor (GEF) for ADP ribosylation factors (ARFs). ARFs, in turn, play a pivotal role in the regulation of vesicular trafficking and membrane dynamics within cells. The activation of BIG1 by these compounds is essential for maintaining the proper flow of cellular cargo through the endomembrane system, impacting processes such as protein secretion, endocytosis, and organelle biogenesis.
Structurally, BIG1 activators often possess distinctive features that enable them to bind specifically to BIG1 and induce conformational changes necessary for its activation. These compounds may interact with specific domains or binding sites on BIG1, promoting the exchange of guanine nucleotides and, consequently, modulating the protein's activity. Understanding the molecular mechanisms underlying the interaction between these activators and BIG1 provides valuable insights into the intricate regulatory networks governing cellular trafficking.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Inhibits GDP-GTP exchange on ARFs, potentially stimulating BIG1's role as an ARF GEF | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Disrupts endosomal and Golgi apparatus function, potentially enhancing BIG1's role in membrane trafficking | ||||||
Nigericin sodium salt | 28643-80-3 | sc-201518A sc-201518 sc-201518B sc-201518C sc-201518D | 1 mg 5 mg 25 mg 1 g 5 g | $46.00 $112.00 $240.00 $7079.00 $27417.00 | 9 | |
Disrupts endosomal and Golgi apparatus function, potentially enhancing BIG1's role in membrane trafficking | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Disrupts microtubule dynamics, potentially promoting BIG1's role in vesicle transport | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Disrupts microtubule dynamics, potentially promoting BIG1's role in vesicle transport | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Inhibits protein phosphatases PP1 and PP2A, potentially promoting signaling pathways related to BIG1 activity | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylyl cyclase, potentially promoting signaling pathways related to BIG1 activity | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Inhibits PI3K, potentially promoting BIG1's role in intracellular trafficking | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Inhibits tyrosine kinases, potentially promoting signaling pathways and cellular processes related to BIG1 activity | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Inhibits HDAC, potentially promoting gene expression and the production of proteins related to BIG1's function | ||||||