β Enolase Activators
β-Enolase, also known as enolase 3 (ENO3), is one of the isoforms of the enzyme enolase, which catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in the glycolysis pathway. The different enolase isoforms are expressed in various tissues, with β-enolase predominantly found in muscle tissues. Enolase, in general, is a metalloenzyme that requires divalent metal ions, typically magnesium, for its activity. The enzyme exists as a dimer, and its structure is highly conserved across different species.
β-Enolase activators are compounds or molecules that enhance the activity of the β-enolase enzyme. The mechanism by which these activators function can vary. Some might bind directly to the enzyme and induce conformational changes that increase its catalytic efficiency. Others might facilitate the binding of substrates or the necessary cofactors to the active site of the enzyme. There might also be activators that protect β-enolase from inhibition or degradation. It's important to understand the distinction between activators and substrates, as the former modulate enzyme activity, while the latter are the molecules upon which the enzyme acts. Furthermore, the specificity of these activators can be crucial. While some activators might enhance the activity of multiple enolase isoforms, others could be more selective for β-enolase, particularly given its distinct tissue distribution. Studying these activators can offer deeper insights into the biochemistry of β-enolase and the intricate regulatory networks of cellular metabolism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a natural polyphenol found in grapes and red wine, can stimulate the AMP-activated protein kinase (AMPK) pathway. Activation of AMPK can lead to the upregulation of glycolytic enzymes, potentially including β Enolase. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin is an antidiabetic drug that activates AMPK. The activation of AMPK promotes glucose uptake and glycolysis, which may induce the expression of enzymes involved in glycolysis, including β Enolase. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR is an AMPK activator. Similar to the previous compounds, its activation of AMPK can stimulate glycolysis and potentially upregulate β Enolase expression in muscle cells. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine is a bioactive compound that can also activate AMPK. By promoting the AMPK pathway, it may stimulate the expression of β Enolase in muscle tissues. | ||||||
Rutin trihydrate | 250249-75-3 | sc-204897 sc-204897A sc-204897B | 5 g 50 g 100 g | $56.00 $71.00 $124.00 | 7 | |
Rutin, a flavonoid glycoside, has been shown to enhance the expression of proteins related to energy metabolism in certain contexts. This might include the induction of glycolytic enzymes such as β Enolase. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is known to stimulate cAMP production. Elevated cAMP can lead to the activation of PKA, which might play a role in the induction of glycolytic enzymes, possibly including β Enolase. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine can lead to increased calcium release in muscle cells. This change in calcium might influence energy metabolism and potentially the expression of β Enolase. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been reported to modulate various cellular pathways. Some studies suggest it might influence energy metabolism and could thereby affect β Enolase expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin can influence mitochondrial biogenesis and function. This flavonoid might play a role in the modulation of glycolytic enzymes, including β Enolase. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a catechin from green tea, has effects on energy metabolism. It's plausible that it might induce the expression of enzymes in the glycolytic pathway like β Enolase. | ||||||