Bestrophin-4 Activators
Bestrophin-4 is a protein encoded by the BEST4 gene and belongs to the family of bestrophins, which function as calcium-activated chloride channels. These channels play a crucial role in the regulation of ion transport across cellular membranes and have been implicated in maintaining cellular ion homeostasis. Bestrophin-4 is particularly interesting due to its tissue-specific expression and potential role in physiological processes. The regulation of Bestrophin-4 expression is a complex interplay of cellular mechanisms that respond to various intracellular and extracellular signals. Research into the factors that can induce the expression of Bestrophin-4 has revealed a range of chemical compounds that can act as activators. These activators can influence the expression of the protein by engaging with different molecular pathways and mechanisms within the cell, leading to an increase in the Bestrophin-4 gene transcription and protein synthesis.
Chemical activators of Bestrophin-4 expression span a diverse array of compounds, each with the capacity to interact with cellular components in a unique manner. For instance, some compounds may bind to specific receptors on the cell surface or within the cell, triggering a cascade of signaling events that culminate in the activation of transcription factors specific to the BEST4 gene. These transcription factors then bind to the promoter region of the gene, initiating the transcription process. Other activators may work epigenetically, altering the chromatin structure around the BEST4 gene, making it more accessible to the transcriptional machinery. Some activators might also function by inhibiting enzymes that add repressive marks to the gene or the histones around which the DNA is wrapped, thereby easing the transcriptional activation of the gene. Understanding the interaction between these chemical compounds and the cellular pathways that govern Bestrophin-4 expression is essential for unraveling the physiological roles of this intriguing protein and the broader implications of its regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid may upregulate Bestrophin-4 by binding to retinoic acid receptors, which then binds to retinoic acid response elements in the gene's promoter region, enhancing transcription. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin could stimulate Bestrophin-4 expression by elevating intracellular cAMP, which in turn activates protein kinase A, leading to the phosphorylation of transcription factors that promote gene transcription. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Cholecalciferol may increase the transcription of Bestrophin-4 by interacting with the vitamin D receptor, which then forms a heterodimer with the retinoid X receptor that can bind to vitamin D response elements in the gene's promoter. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A could induce Bestrophin-4 expression by inhibiting histone deacetylases, leading to chromatin remodeling and facilitating transcription factor access to the DNA. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2′-Deoxycytidine may upregulate Bestrophin-4 by inducing DNA demethylation, which could remove silencing marks and allow transcription factors to initiate gene expression. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
β-Estradiol could stimulate the transcription of Bestrophin-4 by binding estrogen receptors that interact with estrogen response elements on the gene's promoter, initiating transcription. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate may upregulate Bestrophin-4 by inhibiting histone deacetylase, leading to an accumulation of acetylated histones and a consequent increase in gene expression due to a more open chromatin state. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate could stimulate Bestrophin-4 expression by inhibiting DNA methyltransferases, potentially leading to hypomethylation of the gene promoter and activation of transcription. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol may induce Bestrophin-4 expression by activating sirtuin 1, which can deacetylate histone proteins and transcription factors, thereby promoting gene expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin could increase Bestrophin-4 transcript levels by suppressing NF-κB signaling, which might otherwise repress transcription, thereby allowing expression to proceed. | ||||||