Bclp2 Activators
Chil5, or Chitinase-like 5, plays a pivotal role in various biological processes, including the positive regulation of chemokine production, chitin catabolism, and the production of molecular mediators involved in inflammatory responses. Its predicted functions, such as chitin binding and kinase binding activities, suggest its involvement in intricate cellular processes associated with immune regulation and inflammatory signaling. Chil5 is located in the extracellular space, indicating its potential role in mediating extracellular events and responses. The activation of Chil5 is intricately linked to specific cellular signaling pathways, and various chemicals have been identified as potential activators. These chemicals modulate key pathways, including NF-κB, PI3K/Akt, JAK/STAT, MAPK, and Wnt/β-catenin, influencing Chil5 expression and function. For instance, quercetin activates Chil5 through NF-κB modulation, while resveratrol influences AMPK signaling. Each activator contributes to the positive regulation of Chil5, emphasizing the complexity and interconnectedness of cellular pathways governing its activity.
Activation of Chil5 by these chemicals highlights its role in orchestrating immune responses and inflammatory processes. Understanding the nuanced interactions between Chil5 and specific signaling cascades provides valuable insights into its potential as a key player in immune regulation. The identified activators offer promising avenues for further research, shedding light on the intricate mechanisms that govern Chil5-mediated functions and their implications in health and disease.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a natural flavonoid, activates Chil5 by modulating the NF-κB pathway. Acting as an anti-inflammatory agent, it inhibits IκB kinase, preventing NF-κB translocation. This, in turn, upregulates Chil5 expression, contributing to the positive regulation of chemokine production and dampening the inflammatory response. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates Chil5 by influencing the AMP-activated protein kinase (AMPK) pathway. Through AMPK activation, it regulates cellular energy status and positively modulates Chil5, promoting chitin catabolism and mitigating inflammatory responses. The interaction between resveratrol and AMPK contributes to Chil5-mediated processes, including the production of molecular mediators involved in inflammation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG activates Chil5 by targeting the PI3K/Akt signaling pathway. By inhibiting Akt phosphorylation, EGCG promotes the expression of Chil5, leading to enhanced chitin catabolism and positive regulation of chemokine production. This molecular modulation by EGCG highlights its potential role in regulating Chil5-mediated processes involved in inflammatory responses. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin activates Chil5 through the modulation of the JAK/STAT pathway. By inhibiting JAK phosphorylation, curcumin promotes Chil5 expression, positively influencing chitin catabolic processes and the production of molecular mediators related to inflammation. The interaction between curcumin and JAK/STAT signaling suggests its potential role in regulating Chil5-mediated functions in inflammatory contexts. | ||||||
Naringenin | 480-41-1 | sc-219338 | 25 g | $245.00 | 11 | |
Naringenin activates Chil5 by regulating the MAPK pathway. Inhibiting MAPK phosphorylation, naringenin enhances Chil5 expression, contributing to chitin catabolism and the positive regulation of chemokine production. This modulation of Chil5 by naringenin underscores its potential as a regulator of inflammatory responses through the manipulation of key cellular signaling pathways. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $26.00 $50.00 $99.00 $150.00 $1887.00 | 40 | |
Luteolin activates Chil5 by targeting the Wnt/β-catenin signaling pathway. Inhibiting GSK-3β activity, luteolin stabilizes β-catenin, leading to increased Chil5 expression. This molecular interaction promotes chitin catabolic processes and positively regulates chemokine production, highlighting luteolin's potential in modulating Chil5-mediated functions associated with inflammatory responses. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein activates Chil5 by influencing the NF-κB pathway. By inhibiting IκB kinase, genistein prevents NF-κB translocation, promoting Chil5 expression. This molecular interaction contributes to the positive regulation of chemokine production and modulation of the inflammatory response, showcasing genistein as a potential regulator of Chil5-mediated functions in inflammatory contexts. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $97.00 $212.00 $500.00 | 11 | |
Kaempferol activates Chil5 by modulating the PI3K/Akt signaling pathway. Inhibiting Akt phosphorylation, kaempferol enhances Chil5 expression, positively influencing chitin catabolism and the production of molecular mediators involved in inflammation. The interaction between kaempferol and PI3K/Akt signaling suggests its potential role in regulating Chil5-mediated functions in the context of inflammatory responses. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
Apigenin activates Chil5 through the regulation of the JAK/STAT pathway. Inhibiting JAK phosphorylation, apigenin promotes Chil5 expression, positively influencing chitin catabolic processes and the production of molecular mediators related to inflammation. This modulation of Chil5 by apigenin highlights its potential as a regulator of inflammatory responses through the manipulation of key cellular signaling pathways. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $31.00 $41.00 $159.00 $286.00 | 12 | |
Baicalein activates Chil5 by targeting the MAPK pathway. Inhibiting MAPK phosphorylation, baicalein enhances Chil5 expression, contributing to chitin catabolism and the positive regulation of chemokine production. This modulation of Chil5 by baicalein underscores its potential as a regulator of inflammatory responses through the manipulation of key cellular signaling pathways. | ||||||