BCAM Activators
BCAM, or Basal Cell Adhesion Molecule, also known as Lutheran blood group glycoprotein, is a member of the immunoglobulin superfamily and is involved in cell adhesion processes. BCAM functions as a receptor for laminin, an extracellular matrix protein, and plays a role in various cellular processes, including cell migration, differentiation, and survival. BCAM activators are a class of chemicals designed to enhance the functional activity of BCAM, affecting its interaction with laminin or its signaling pathways.
Direct BCAM activators can potentially bind to the extracellular domain of BCAM, promoting its adhesion to laminin, or they might induce conformational changes that increase its affinity for this matrix protein. This can enhance cell attachment, spreading, or migration. Additionally, activators can interact with the intracellular domain of BCAM, enhancing its ability to initiate downstream signaling pathways upon binding to laminin. Indirect BCAM activators function by upregulating the expression of the BCAM gene, leading to increased synthesis of the protein and, consequently, heightened adhesion potential. They also act on the post-translational modifications of BCAM, such as glycosylation patterns, which can affect its stability, localization, and interaction with laminin. Furthermore, indirect activators may influence signaling pathways that intersect with BCAM functions, modulating the cell's overall adhesive properties or its response to the extracellular matrix.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that can indirectly modulate BCAM by suppressing the MAPK pathway, altering the phosphorylation state and thus the function of BCAM. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor that can indirectly affect BCAM by inhibiting the PI3K/Akt pathway, which plays a role in BCAM-mediated cell adhesion and migration. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a tyrosine kinase inhibitor which can indirectly modulate BCAM by inhibiting tyrosine kinases, thereby affecting the phosphorylation status of BCAM. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that can indirectly modulate BCAM by suppressing the p38 MAPK pathway, thereby altering the phosphorylation status and thus the function of BCAM. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
AG490 is a JAK2 inhibitor that can indirectly modulate BCAM by suppressing the JAK-STAT pathway, thereby affecting the phosphorylation status of BCAM. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 is an IκBα phosphorylation inhibitor that can indirectly modulate BCAM by suppressing the NF-κB pathway, thereby altering the phosphorylation state and thus the function of BCAM. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a Src inhibitor that can indirectly affect BCAM by inhibiting Src tyrosine kinases, which play a role in BCAM-mediated cell adhesion and migration. | ||||||