BC066135 Activators
Rbbp8nl, an N-terminal like protein orthologous to human RBBP8NL, is implicated in various cellular processes, likely functioning in chromatin dynamics and gene regulation within the nucleus. Its precise role and activation mechanisms are intricately tied to epigenetic modifications and chromatin remodeling. Activation of Rbbp8nl is influenced by various chemical modulators. HDAC inhibitors like Vorinostat, Trichostatin A, and Sodium Butyrate enhance Rbbp8nl activity by promoting histone acetylation and altering chromatin structure, facilitating its engagement with DNA. Compounds like JQ1, a BET bromodomain inhibitor, modulate chromatin accessibility, enabling Rbbp8nl to exert its transcriptional regulatory function. PARP inhibitors like A-485 and DNA methyltransferase inhibitors like Azacitidine and 5-Azacytidine affect epigenetic modifications, potentially enhancing Rbbp8nl activation by influencing DNA methylation and histone acetylation.
Natural compounds such as Curcumin, Resveratrol, and Betulinic Acid exert their effects through anti-inflammatory mechanisms and epigenetic modulation, likely impacting Rbbp8nl's role in chromatin dynamics. Understanding the activation mechanisms of Rbbp8nl sheds light on its significance in cellular processes and provides valuable insights into strategies targeting its regulatory functions within the nucleus.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
HDAC inhibitor impacting chromatin structure. Potential indirect activator of Rbbp8nl by inhibiting HDACs, leading to increased histone acetylation and altered chromatin accessibility. Vorinostat's role involves epigenetic modifications that enhance Rbbp8nl's binding to DNA, promoting its activation in the nucleus. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
HDAC inhibitor affecting epigenetic regulation. Potential indirect activator of Rbbp8nl by inhibiting HDACs, leading to histone acetylation and altered chromatin structure. Trichostatin A's role involves promoting Rbbp8nl activation through epigenetic modifications, facilitating its engagement with chromatin and participation in cellular processes. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
HDAC inhibitor modulating gene expression. Potential indirect activator of Rbbp8nl by inhibiting HDACs, leading to increased histone acetylation and altered chromatin accessibility. Sodium Butyrate's role involves epigenetic modifications that enhance Rbbp8nl's binding to DNA, promoting its activation in the nucleus. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
BET bromodomain inhibitor impacting gene transcription. Potential indirect activator of Rbbp8nl by inhibiting bromodomain proteins, altering chromatin structure, and influencing Rbbp8nl activity. JQ1's role involves modulating the epigenetic landscape to facilitate Rbbp8nl binding to chromatin, enhancing its transcriptional regulatory function in the nucleus. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
DNA methyltransferase inhibitor impacting DNA methylation. Potential indirect activator of Rbbp8nl by demethylating cis-regulatory regions, promoting histone acetylation, and influencing chromatin accessibility. Azacitidine's role involves epigenetic modifications that enhance Rbbp8nl binding to DNA, facilitating its activation in the nucleus. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Natural polyphenol affecting multiple signaling pathways. Potential indirect activator of Rbbp8nl through its anti-inflammatory and epigenetic modulation, influencing chromatin accessibility. Curcumin's role involves suppressing inflammatory pathways and modifying chromatin structure to enhance Rbbp8nl activation in the nucleus. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Polyphenolic compound with diverse cellular effects. Potential indirect activator of Rbbp8nl through its antioxidant and epigenetic modulating properties. Resveratrol's role may involve influencing chromatin structure and promoting Rbbp8nl activation, facilitating its engagement in cellular processes within the nucleus. | ||||||
A-485 | 1889279-16-6 | sc-507493 | 5 mg | $275.00 | ||
PARP inhibitor impacting chromatin structure. Potential indirect activator of Rbbp8nl through PARP inhibition, influencing histone acetylation and chromatin accessibility. A-485's role involves modulating the chromatin environment to facilitate Rbbp8nl binding to DNA, promoting its activation in the nucleus. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Natural triterpenoid impacting multiple pathways. Potential indirect activator of Rbbp8nl through its anti-inflammatory and epigenetic modulating properties. Betulinic Acid's role involves influencing chromatin accessibility and promoting Rbbp8nl activation, facilitating its engagement in cellular processes within the nucleus. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
DNA methyltransferase inhibitor impacting DNA methylation. Potential indirect activator of Rbbp8nl by demethylating cis-regulatory regions, promoting histone acetylation, and influencing chromatin accessibility. Decitabine's role involves epigenetic modifications that enhance Rbbp8nl binding to DNA, facilitating its activation in the nucleus. | ||||||