BC057170 Inhibitors
Chemical inhibitors of BC057170 act through diverse mechanisms to modulate the activity of this protein. Staurosporine is a broad-spectrum protein kinase inhibitor that can impede protein kinase C, a kinase that may play a role in the signaling pathways involving BC057170. This inhibition can lead to decreased phosphorylation and subsequent activation of proteins that interact with BC057170, effectively reducing its activity. Similarly, LY294002 and Wortmannin both target PI3K, a kinase that participates in the PI3K/Akt signaling pathway, which is crucial for cell survival. The inhibition of PI3K by these chemicals can result in a reduction of Akt signaling, which can decrease the functional activity of BC057170 if it is reliant on this pathway. Rapamycin, another inhibitor, binds to FKBP12 to inhibit mTOR, which is a central regulator of cell growth. The inhibition of mTOR can attenuate the activity of BC057170 if mTOR signaling is important for its function.
Additionally, PD98059 and U0126 target the MEK enzymes upstream of ERK in the MAPK pathway. By inhibiting MEK, these compounds can block the phosphorylation and activation of ERK, which can lead to a reduction in BC057170 activity if ERK signaling is involved in its function. SB203580 and SP600125 inhibit the stress-activated p38 MAPK and JNK pathways, respectively. The inhibition of these kinases can decrease the activity of BC057170 if it is modulated by stress-activated signaling pathways. PP2, an Src family tyrosine kinase inhibitor, disrupts various signaling cascades that can diminish the activity of BC057170 if it is associated with Src signaling. LY3214996 selectively inhibits ERK1 and ERK2, which can reduce BC057170 activity if it is dependent on ERK signaling. Lastly, GSK690693 and AZD8055 target Akt and mTOR kinases, respectively. GSK690693 inhibits Akt, which can lead to the downregulation of BC057170 activity if it is part of the Akt pathway, while AZD8055, which inhibits both mTORC1 and mTORC2 complexes, can decrease BC057170 activity if it relies on mTOR signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent protein kinase inhibitor that can inhibit protein kinase C, which is involved in various signaling pathways that BC057170 may be a part of. Inhibition of protein kinase C could lead to decreased phosphorylation and activation of downstream proteins that interact with or regulate BC057170, resulting in functional inhibition. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is an inhibitor of PI3K, a kinase involved in the PI3K/Akt pathway, which is a critical regulator of cell survival and apoptosis. The inhibition of PI3K could lead to reduced signaling through Akt, which may be necessary for the function of BC057170, thereby inhibiting its activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin binds to FKBP12 and the complex inhibits mTOR, a key regulator of cell growth and proliferation. If BC057170 is involved in pathways regulated by mTOR, its inhibition by rapamycin could lead to a decrease in BC057170 activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a specific inhibitor of MEK, a kinase that acts directly upstream of ERK in the MAPK pathway. By inhibiting MEK, PD98059 can reduce ERK activation, potentially leading to decreased activity of BC057170 if it is downstream of this pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is an inhibitor of p38 MAPK, a kinase involved in response to stress signals. Inhibition of p38 MAPK can reduce the activity of proteins that are regulated by stress-activated pathways, potentially inhibiting BC057170 if it is functionally connected to this pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, which is involved in cellular stress and apoptosis pathways. By inhibiting JNK, SP600125 could lead to the inhibition of BC057170 if its function is regulated by JNK signaling. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent inhibitor of PI3K like LY294002, but it acts in a different manner. It covalently binds to and inhibits PI3K, possibly leading to reduced BC057170 activity if PI3K signaling is necessary for its function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a selective inhibitor of MEK1 and MEK2, like PD98059. By inhibiting these MEK enzymes, U0126 can block ERK phosphorylation and activation, potentially inhibiting BC057170 if it is a downstream effector in the MAPK pathway. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is an Src family tyrosine kinase inhibitor. Inhibition of Src kinases can disrupt various signaling cascades, potentially leading to the inhibition of BC057170 if it relies on Src signaling for its activity. | ||||||
GSK 690693 | 937174-76-0 | sc-363280 sc-363280A | 10 mg 50 mg | $255.00 $1071.00 | 4 | |
GSK690693 is an inhibitor of Akt, a serine/threonine-specific protein kinase involved in cell survival and apoptosis pathways. Inhibition of Akt by GSK690693 could lead to the functional inhibition of BC057170 if it is part of or regulated by the Akt pathway. | ||||||