Barx1 Activators
Barx1 Activators encompass a diverse array of chemical compounds that enhance the functional activity of Barx1 through distinct signaling mechanisms and molecular interactions. Forskolin and Dibutyryl-cAMP, by increasing intracellular cAMP levels, activate protein kinase A (PKA), which can phosphorylate transcription factors and other proteins that enhance the transcriptional regulation capabilities of Barx1. This activation process is crucial, as PKA-mediated phosphorylation typically results in the amplification of transcriptional responses that Barx1 is involved in. In parallel, the histone deacetylase inhibitors Sodium butyrate and Trichostatin A (TSA) remodel chromatin architecture around genes where Barx1 functions as a transcriptional regulator. By increasing histone acetylation, these inhibitors facilitate the accessibility of Barx1 to its target DNA sequences, thereby potentiating its transcriptional activity without altering its expression levels.
Additionally, the biochemical landscape that Barx1 operates within is fine-tuned by compounds like Lithium chloride, which inhibits GSK-3, and Epigallocatechin gallate, a kinase inhibitor. These compounds lead to changes in the phosphorylation state of various proteins that interact with or co-regulate gene expression alongside Barx1, thus indirectly enhancing its function. Retinoic acid, by modulating gene expression through its receptors, can also synergize with Barx1 on specific gene promoters, potentially augmenting Barx1's transcriptional influence. Zinc sulfate serves a critical role as a cofactor, bolstering the DNA-binding ability of Barx1 and its associated proteins, which is fundamental to its activation. Collectively, these Barx1 Activators, through targeted molecular interactions and signaling modifications, create a conducive environment for the maximization of Barx1's role in gene regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases intracellular cAMP levels, which enhances Barx1 by activating protein kinase A (PKA). PKA then phosphorylates transcription factors that can lead to the upregulation of genes controlled by BARX1, hence enhancing its activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, leading to an increase in cAMP and cGMP levels in cells. This elevation can potentiate PKA activity, which in turn can enhance the transcriptional activity of Barx1 by phosphorylation of transcriptional machinery. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
This catechin inhibits several protein kinases, which might lead to a reduced phosphorylation of inhibitory sites on transcription factors regulated by Barx1, thus enhancing Barx1's ability to regulate gene expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3 which is involved in several signaling pathways. Inhibition of GSK-3 can lead to stabilization and activation of transcription factors that increase the expression of genes under the control of Barx1. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
As a histone deacetylase inhibitor, sodium butyrate can lead to a more open chromatin structure around the BARX1 gene, potentially enhancing the transcriptional activity of Barx1. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid modulates gene expression through its receptors, which can interact with Barx1 on certain gene promoters, potentially enhancing the transcriptional activity of Barx1 on these genes. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA, another histone deacetylase inhibitor, can increase acetylation of histones near the BARX1 gene, enhancing the transcriptional activity of Barx1 by allowing easier access of transcriptional activators to the DNA. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound is a DNA methyltransferase inhibitor which can lead to hypomethylation of the BARX1 gene promoter, potentially enhancing transcription and thus Barx1 activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which may enhance Barx1 activity by phosphorylation of transcription factors that work synergistically with Barx1 in gene regulation. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc acts as a cofactor for many DNA-binding proteins including those that Barx1 might interact with; an increase in zinc levels could enhance the DNA-binding capability of Barx1, increasing its transcriptional activity. | ||||||