BAF57 Activators
Z39Ig Activators are a collection of compounds that indirectly enhance the activity of Z39Ig, a protein encoded by the VSIG4 gene and implicated in immune regulation. Cyclosporin A and FK-506, both immunosuppressants, play a pivotal role in enhancing Z39Ig's functionality. They achieve this by modulating T-cell responses, which aligns with Z39Ig's role as a negative regulator of T-cell activation. Cyclosporin A, specifically, inhibits calcineurin, thereby indirectly supporting Z39Ig's function in immune suppression. Similarly, corticosteroids like Dexamethasone and Hydrocortisone enhance Z39Ig activity through their anti-inflammatory effects, potentially increasing the expression or stability of Z39Ig and thus augmenting its role in downregulating immune responses.
Furthermore, compounds such as Cholecalciferol and Retinoic Acid contribute to the functionality of Z39Ig by influencing immune cell differentiation and gene expression. Cholecalciferol, for instance, can modulate the expression of genes like VSIG4, potentially upregulating Z39Ig expression and enhancing its immunosuppressive role. Retinoic Acid, all trans also plays a similar role by affecting gene expression patterns. Additionally, immunomodulatory agents like Rapamycin, Mycophenolate Mofetil, Azathioprine, and Methotrexate support Z39Ig's function by creating an immunosuppressive environment, either through inhibiting lymphocyte proliferation or by modulating immune responses. Prednisolone and Aspirin, with their roles in reducing inflammation and modulating immune responses, further aid in enhancing Z39Ig's role in immune regulation. Collectively, these Z39Ig Activators, through their varied mechanisms of action, support and augment the role of Z39Ig in immune suppression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A, an immunosuppressant, can enhance Z39Ig activity by modulating immune responses. Z39Ig, encoded by the VSIG4 gene, is a B7 family-related protein and functions as a negative regulator of T-cell responses. Cyclosporin A's inhibition of calcineurin indirectly supports Z39Ig's function in immune suppression by reducing T-cell activation and proliferation. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone, a corticosteroid, can enhance the activity of Z39Ig by its anti-inflammatory effects. It may increase the expression or stability of Z39Ig, enhancing its role in downregulating immune responses, particularly in T-cell mediated immunity. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Cholecalciferol can enhance Z39Ig activity by influencing immune cell differentiation and function. It can modulate the expression of genes like VSIG4, potentially upregulating Z39Ig expression and enhancing its immunosuppressive role. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid, all trans can enhance Z39Ig activity by modulating immune cell function. It influences gene expression patterns, including those of immune regulatory genes like VSIG4, potentially enhancing Z39Ig's role in immune regulation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin, an mTOR inhibitor, can indirectly enhance Z39Ig activity. By inhibiting mTOR, it affects T-cell activation and differentiation, potentially augmenting Z39Ig's role in suppressing T-cell responses. | ||||||
Mycophenolate mofetil | 128794-94-5 | sc-200971 sc-200971A | 20 mg 100 mg | $36.00 $107.00 | 1 | |
Mycophenolate Mofetil, an immunosuppressant, can enhance Z39Ig activity by inhibiting lymphocyte proliferation. Its impact on immune cells can lead to a favorable environment for Z39Ig's function in immune suppression. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $76.00 $148.00 | 9 | |
FK-506, an immunosuppressant, can enhance Z39Ig activity similarly to Cyclosporin A. By inhibiting T-cell activation, it supports the immunosuppressive role of Z39Ig. | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $100.00 | 6 | |
Hydrocortisone, a corticosteroid, can enhance Z39Ig activity by its anti-inflammatory properties. It potentially increases the expression or stability of Z39Ig, aiding in its role to regulate immune responses. | ||||||
Azathioprine | 446-86-6 | sc-210853D sc-210853 sc-210853A sc-210853B sc-210853C | 500 mg 1 g 2 g 5 g 10 g | $199.00 $173.00 $342.00 $495.00 $690.00 | 1 | |
Azathioprine, an immunosuppressive agent, can enhance Z39Ig activity by inhibiting lymphocyte proliferation. This creates a more favorable environment for Z39Ig's immunosuppressive function. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $41.00 | 4 | |
Aspirin can indirectly enhance Z39Ig activity through its anti-inflammatory properties. By reducing inflammation, it may create conditions that support Z39Ig's function in immune regulation. | ||||||