BAF57 Antibody (6G11): sc-293309
- BAF57 Antibody (6G11) is a mouse monoclonal IgG1 κ BAF57 antibody provided at 100 µg/ml
- raised against amino acids 75-142 of BAF57 of human origin
- recommended for detection of BAF57 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for BAF57 Antibody (6G11). This work is in progress.
QUICK LINKS
BAF57 Antibody (6G11) is a mouse monoclonal IgG1 kappa light chain antibody that detects BAF57 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-BAF57 antibody (6G11) is available as the non-conjugated format. BAF57 plays a crucial role in the SWI/SNF chromatin remodeling complex, which is essential for the regulation of gene expression through the alteration of nucleosome structure in an ATP-dependent manner. This complex is vital for various cellular processes, including differentiation, proliferation, and response to external signals. BAF57 is particularly important as BAF57 interacts with other key components of the SWI/SNF complex, such as Brm and Brg-1, which are ATPase subunits that provide the energy necessary for chromatin remodeling. BAF57′s high-mobility-group (HMG) domain and kinesin-like region allow for effective DNA binding and recruitment of additional factors necessary for transcriptional activation. Notably, BAF57 gene is located in the q12-25 region of chromosome 17, an area associated with breast and ovarian cancers, highlighting BAF57′s significance in cancer biology and potential as a therapeutic target.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
BAF57 Antibody (6G11) References:
- Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits. | Phelan, ML., et al. 1999. Mol Cell. 3: 247-53. PMID: 10078207
- Characterization of SWI/SNF protein expression in human breast cancer cell lines and other malignancies. | Decristofaro, MF., et al. 2001. J Cell Physiol. 186: 136-45. PMID: 11147808
- A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor. | Muchardt, C. and Yaniv, M. 1993. EMBO J. 12: 4279-90. PMID: 8223438
- BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription. | Khavari, PA., et al. 1993. Nature. 366: 170-4. PMID: 8232556
- Nucleosome disruption by human SWI/SNF is maintained in the absence of continued ATP hydrolysis. | Imbalzano, AN., et al. 1996. J Biol Chem. 271: 20726-33. PMID: 8702824
- Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes. | Wang, W., et al. 1998. Proc Natl Acad Sci U S A. 95: 492-8. PMID: 9435219
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BAF57 Antibody (6G11) | sc-293309 | 100 µg/ml | $316.00 |