B7RP-1 Inhibitors
B7RP-1 Inhibitors, belonging to the broader category of immunomodulatory compounds, are a class of chemical substances that have garnered significant attention in the field of molecular biology and immunology. These inhibitors are primarily designed to target the B7RP-1 protein, which plays a pivotal role in regulating immune responses within the human body. B7RP-1, also known as ICOS-L (Inducible T-cell Costimulator Ligand), is a cell surface protein expressed on various antigen-presenting cells, such as dendritic cells and B cells, as well as on non-immune cells like endothelial cells. Its interaction with its corresponding receptor, ICOS (Inducible T-cell Costimulator), on T cells, is crucial for modulating T-cell activation and differentiation.
The mechanism of action of B7RP-1 Inhibitors lies in their ability to disrupt the binding of B7RP-1 to the ICOS receptor on T cells. By inhibiting this interaction, these compounds can interfere with the co-stimulatory signals necessary for T-cell activation and effector functions. This disruption of the B7RP-1/ICOS pathway can have profound effects on immune responses, potentially attenuating excessive immune reactions or inducing tolerance in specific contexts. Research into B7RP-1 Inhibitors is ongoing, with a focus on elucidating their molecular structures and optimizing their efficacy.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
4-Amino-2-chloro-6,7-dimethoxyquinazoline | 23680-84-4 | sc-209917 | 10 g | $300.00 | ||
Palmitoyl-DL-carnitine can modulate signal transduction pathways by affecting lipid rafts and membrane fluidity, which can indirectly influence B7RP-1 mediated signaling. | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $184.00 $321.00 | 1 | |
Perifosine can alter AKT signaling, which is a downstream pathway of B7RP-1, by inhibiting AKT phosphorylation and its subsequent activation. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 can inhibit MEK, a kinase involved in the MAPK/ERK pathway, which may be downstream of B7RP-1 signaling, thereby affecting the protein's influence on cellular processes. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 can inhibit PI3K, a key enzyme in the pathway that can be activated by B7RP-1 signaling, thereby affecting subsequent AKT activation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin can inhibit mTOR, a component of a signaling pathway that may be affected by B7RP-1 activity, thus disrupting downstream signaling events. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin can inhibit PI3K, potentially affecting the B7RP-1 related signaling pathways by preventing the activation of downstream effectors such as AKT. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib can inhibit Src family kinases, which can be involved in signaling pathways associated with B7RP-1, thereby affecting the protein's functional outcomes. | ||||||
Erlotinib, Free Base | 183321-74-6 | sc-396113 sc-396113A sc-396113B sc-396113C sc-396113D | 500 mg 1 g 5 g 10 g 100 g | $85.00 $132.00 $287.00 $495.00 $3752.00 | 42 | |
Erlotinib can inhibit EGFR tyrosine kinase, which may crosstalk with B7RP-1 mediated pathways, thus influencing the protein's functional network. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine can inhibit a broad range of protein kinases, potentially affecting various signaling cascades that B7RP-1 may participate in. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 can inhibit JNK, which may be part of the signaling pathways influenced by B7RP-1, and thus can alter the protein's downstream effects. | ||||||