AURA1 Activators
AURA1 Activators encompass a diverse group of chemical compounds that are known to facilitate the activation of the protein AURA1 through various signaling mechanisms. Each activator operates by either inducing a direct phosphorylation event or by modulating the intracellular environment to favor AURA1 activation. Forskolin, for example, functions by elevating cAMP levels, which triggers PKA activation; PKA then directly phosphorylates AURA1, leading to an enhancement of its kinase activity. Similarly, PMA acts through PKC, which also targets AURA1 for phosphorylation. Ionomycin and A23187, on the other hand, raise intracellular calcium levels, indirectly promoting AURA1 activation through calcium-dependent kinases. Epidermal Growth Factor (EGF) operates at the receptor level, where binding to EGFR activates downstream kinases that then act on AURA1. In contrast, Anisomycin, through the activation of SAPKs such as JNK, and Hydrogen Peroxide, through oxidative stress pathways, can lead to the activation of AURA1.
Moreover, the activity of AURA1 is not only regulated by kinase-driven phosphorylation but also by the prevention of dephosphorylation. Compounds like Calyculin A and Okadaic Acid inhibit phosphatases that would otherwise deactivate AURA1, thus keeping it in an active state. Thapsigargin indirectly contributes to AURA1 activation by disrupting calcium homeostasis via SERCA inhibition, which then affects calcium-dependent kinase activities linked to AURAI apologize for the mistake in the previous response.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate AURA1, leading to its direct activation and enhancement of its kinase activity. | ||||||
Phorbol | 17673-25-5 | sc-253267 | 5 mg | $270.00 | 1 | |
Phorbol 12-myristate 13-acetate (PMA) is a potent protein kinase C (PKC) activator. PKC activation can lead to the phosphorylation of AURA1 at specific serine/threonine residues, enhancing its kinase function. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin elevates intracellular calcium levels, which activates calmodulin-dependent kinases. These kinases can phosphorylate AURA1, enhancing its activity as part of calcium signaling cascades. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin activates stress-activated protein kinases (SAPKs) such as JNK. JNK can phosphorylate AURA1, enhancing its kinase function within stress response pathways. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A inhibits protein phosphatase 1 and 2A, preventing dephosphorylation of proteins. This maintains AURA1 in a phosphorylated, active state within cellular signaling pathways. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid inhibits serine/threonine protein phosphatases. This inhibition can lead to an increase in the phosphorylated form of AURA1, maintaining its activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), causing an increase in cytosolic calcium levels, which indirectly activates AURA1 through calcium-dependent signaling pathways. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Hydrogen peroxide acts as a signaling molecule that can lead to the activation of oxidative stress response pathways. These pathways can phosphorylate and activate AURA1. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cAMP analog that activates PKA. PKA can then phosphorylate AURA1, enhancing its functional activity in various signaling cascades. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium, similarly to ionomycin, activating calcium-dependent kinases that can enhance the phosphorylation and activity of AURA1. | ||||||