ATP8B2 Activators
ATP8B2 is an integral membrane protein that plays a crucial role in the maintenance of cellular lipid asymmetry, which is pivotal for various cellular functions including vesicle formation, cell signaling, and apoptosis. As a member of the P4-ATPase family of phospholipid flippases, ATP8B2 actively transports specific phospholipids from the outer to the inner leaflet of the cellular membrane, thus preserving the essential lipid composition of cell membranes. The precise regulation of ATP8B2 expression is essential for cellular homeostasis, and a complex network of transcriptional mechanisms underlies the control of its gene's activation. Understanding the molecular triggers that can enhance the expression of ATP8B2 is of significant interest in the field of cellular biology, as it can reveal insights into the fundamental processes governing cell membrane dynamics and integrity.
Several chemical compounds have been identified as potential activators of ATP8B2 expression, each acting through distinct biochemical pathways. For instance, retinoic acid is known to initiate transcriptional activation of genes involved in cell differentiation and may play a role in upregulating ATP8B2 to support changes in membrane composition during this process. Similarly, forskolin, by elevating cAMP levels, could initiate a cascade that ends in the transcription of ATP8B2, reflecting the need for enhanced lipid transport mechanisms under conditions of increased signaling activity. Compounds like sodium butyrate and 5-azacytidine could alter chromatin structure and DNA methylation, respectively, leading to a more open chromatin configuration that makes the ATP8B2 gene more accessible for transcription. Additionally, agents such as PMA or eicosapentaenoic acid can activate specific transcription factors or nuclear receptors, which may directly bind to the promoter regions of membrane-associated proteins like ATP8B2, stimulating their expression. These activators highlight the diversity of cellular signals that converge on the regulation of ATP8B2, underscoring the complexity of cellular lipid regulation and the exquisite control cells exert over membrane composition and function.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can initiate transcriptional activation of genes associated with cell differentiation and may specifically upregulate ATP8B2 to support membrane remodeling. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin raises intracellular cAMP levels, which could trigger a signaling cascade culminating in the increased transcription of genes like ATP8B2 that are pivotal for lipid transport. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This demethylating agent can reactivate silenced genes by altering DNA methylation status, potentially resulting in the enhanced transcription of ATP8B2. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA's activation of PKC can lead to the activation of transcription factors that specifically stimulate the expression of membrane-associated proteins, including ATP8B2. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride may promote the expression of stress response proteins and could specifically induce ATP8B2 synthesis as part of a cellular protective mechanism. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate can lead to the hyperacetylation of histone proteins, potentially triggering enhanced transcription of ATP8B2 by making its promoter more accessible to transcriptional machinery. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
This hormone can bind to and activate estrogen receptors, which may directly bind to regulatory regions of genes like ATP8B2, leading to its increased transcription. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
As a PPARγ agonist, rosiglitazone can initiate the transcription of genes involved in lipid metabolism by binding to PPAR response elements, potentially including the promoter of ATP8B2. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin might activate transcription factors such as NF-kB, which could lead to the upregulation of genes like ATP8B2 that are involved in the cellular stress response. | ||||||
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $104.00 $431.00 | ||
EPA can activate transcription factors that govern lipid metabolism and might specifically stimulate the enhanced transcription of ATP8B2, reflecting its role in phospholipid flipping. | ||||||