ATP6L Activators
The ATP6L Activators class encompasses chemicals that indirectly affect the ATP6L protein, which is a key component of the V-ATPase complex. These compounds primarily function by disrupting ion gradients or pH balance within cells, thereby potentially inducing a compensatory response that could influence ATP6L activity. For instance, activators are known to disrupt pH gradients, potentially triggering a compensatory response to restore pH balance, which could involve the activation of ATP6L.
Additionally, ATP6L Activators disrupt ion gradients across cellular membranes. This disruption could instigate a cellular response to restore ion balance and pH, potentially involving the activation of ATP6L. On the other hand, activators influence protein cross-linking and potentially endosomal maturation, which could indirectly affect ATP6L if the protein's function is linked with these processes. Activators could also bind to regulatory regions of the protein, inducing conformational changes that either expose the active site more effectively to its substrates or increase its affinity for ATP. Alternatively, activators might work indirectly by influencing the expression levels of the gene encoding ATP6L, increasing the amount of the protein synthesized by the cell.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine is a weak base that accumulates in acidic organelles, disrupting the pH gradient. This can indirectly activate ATP6L as the cell attempts to reestablish the pH gradient. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 is a specific inhibitor of V-ATPase, which leads to alkalinization of acidic compartments. This could cause a compensatory upregulation and activation of ATP6L to restore the pH gradient. | ||||||
FCM Lysing solution (1x) | sc-3621 | 150 ml | $61.00 | 8 | ||
Ammonium chloride is a weak base that can disrupt the pH gradient in cellular organelles. This disruption may lead to an indirect activation of ATP6L. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin is an ionophore that disrupts pH and ion gradients across membranes. Changes in intracellular pH may indirectly stimulate ATP6L activity. | ||||||
Nigericin sodium salt | 28643-80-3 | sc-201518A sc-201518 sc-201518B sc-201518C sc-201518D | 1 mg 5 mg 25 mg 1 g 5 g | $45.00 $110.00 $235.00 $6940.00 $26879.00 | 9 | |
Nigericin is a potassium ionophore that disrupts the proton gradient, potentially leading to an indirect increase in ATP6L activity. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $92.00 $348.00 | 46 | |
FCCP dissipates proton gradients across membranes, potentially causing a compensatory activation of ATP6L. | ||||||
2,4-Dinitrophenol, wetted | 51-28-5 | sc-238345 | 250 mg | $58.00 | 2 | |
DNP is a proton ionophore, disrupting proton gradients and potentially leading to an indirect activation of ATP6L. | ||||||
Valinomycin | 2001-95-8 | sc-200991 | 25 mg | $163.00 | 3 | |
Valinomycin is a potassium ionophore, disrupting ion gradients and potentially causing a compensatory activation of ATP6L. | ||||||
Concanamycin A | 80890-47-7 | sc-202111 sc-202111A sc-202111B sc-202111C | 50 µg 200 µg 1 mg 5 mg | $65.00 $162.00 $650.00 $2550.00 | 109 | |
Concanamycin A is a specific inhibitor of V-ATPase. Its usage can lead to a compensatory activation of ATP6L to restore the pH gradient. | ||||||
Carbonyl Cyanide m-Chlorophenylhydrazone | 555-60-2 | sc-202984A sc-202984 sc-202984B | 100 mg 250 mg 500 mg | $75.00 $150.00 $235.00 | 8 | |
CCCP is a protonophore that disrupts proton gradients, which can lead to a compensatory activation of ATP6L. | ||||||