ATF-7 Inhibitors
ATF-7 inhibitors are a class of chemical compounds designed to target and modulate the activity of the Activating Transcription Factor 7 (ATF-7) protein. ATF-7 is a member of the ATF/CREB (cAMP response element-binding protein) family of transcription factors that play a critical role in the regulation of gene expression. These transcription factors bind to specific DNA sequences in the promoter regions of target genes, thereby modulating their transcription. ATF-7, in particular, has been implicated in various cellular processes, including stress responses, cell cycle regulation, and immune system functions. Inhibitors of ATF-7 are developed to interact with this transcription factor, disrupting its binding to target gene promoters and influencing downstream gene expression patterns.
Typically, ATF-7 inhibitors are small molecules or compounds designed to bind to ATF-7, affecting its ability to interact with DNA or other regulatory proteins involved in transcriptional regulation. By doing so, these inhibitors may alter the transcriptional activity of ATF-7 and its target genes, leading to changes in cellular responses or functions related to ATF-7 activity. Research into ATF-7 inhibitors is essential for understanding the molecular mechanisms underlying gene regulation and the roles played by ATF-7 in various cellular processes, shedding light on its involvement in stress responses, cell proliferation, and immune system modulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide is known to inhibit the expression of various transcription factors by interfering with transcriptional machinery, potentially decreasing ATF-7 levels. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
This compound intercalates into DNA, preventing RNA synthesis, which could lead to a reduction in ATF-7 mRNA transcripts and protein levels. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
α-Amanitin inhibits RNA polymerase II, which is crucial for mRNA synthesis, possibly resulting in decreased ATF-7 expression. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1, a BET bromodomain inhibitor, may downregulate transcription factors like ATF-7 by altering chromatin accessibility and transcriptional activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 inhibits the proteasome, leading to altered protein turnover; it may indirectly affect ATF-7 stability and expression levels. | ||||||
KPT 330 | 1393477-72-9 | sc-489062 | 5 mg | $173.00 | ||
This selective inhibitor of nuclear export (SINE) could potentially reduce ATF-7 levels by altering its nuclear-cytoplasmic transport. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
A cyclin-dependent kinase inhibitor that impedes transcription elongation, which might decrease the expression of transcription factors like ATF-7. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
A histone acetyltransferase p300 inhibitor that may downregulate transcription factors including ATF-7 by changing gene expression patterns. | ||||||
Sirtinol | 410536-97-9 | sc-205976 sc-205976A | 1 mg 5 mg | $38.00 $113.00 | 14 | |
By inhibiting SIRT1, sirtinol could alter histone deacetylation patterns, potentially affecting ATF-7 expression. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 inhibits NF-κB activity, which might lead to downregulation of ATF-7 expression through modulation of signaling pathways. | ||||||