Date published: 2025-10-10

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AT2 Activators

The angiotensin II type 2 receptor (AT2) is one of the receptors that mediate the effects of angiotensin II (Ang II). It has various physiological and pathophysiological roles, especially in cardiovascular function, cell growth, and inflammation. AT2 Activators are compounds that stimulate or regulate the activity of the Angiotensin II type 2 receptor (AT2 receptor), a critical component of the renin-angiotensin system. Unlike its counterpart, the Angiotensin II type 1 receptor (AT1 receptor), which is known for its vasoconstrictive and pro-inflammatory effects, the AT2 receptor typically exerts vasodilatory, anti-inflammatory, and tissue-regenerative actions. AT2 Activators, therefore, play a pivotal role in exploring the balance between these two receptors' activities and understanding their influence on cardiovascular health, inflammation, and tissue repair processes. Activation of the AT2 receptor can lead to various physiological responses, including the relaxation of blood vessels, suppression of inflammation, and promotion of tissue repair and regeneration. Research into AT2 Activators contributes to unraveling the intricate mechanisms governing the renin-angiotensin system, with implications for conditions like hypertension and tissue injury. The study of AT2 Activators is crucial for expanding our knowledge of the renin-angiotensin system's complexities and its role in both health and disease.

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Items 1 to 10 of 13 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Angiotensin fragment 1-7 acetate salt

51833-78-4sc-319824
1 mg
$82.00
1
(1)

Angiotensin fragment 1-7 acetate salt acts as a potent AT2 receptor activator, showcasing unique molecular interactions that enhance its affinity for receptor binding. Its peptide structure allows for specific conformational changes upon binding, triggering distinct intracellular signaling cascades. The acetate salt form improves solubility and stability, facilitating efficient cellular uptake. This compound's behavior is characterized by rapid kinetics, promoting swift physiological responses in target tissues.

Angiotensin II, Human

4474-91-3sc-363643
sc-363643A
sc-363643B
sc-363643C
1 mg
5 mg
25 mg
100 mg
$50.00
$75.00
$260.00
$505.00
3
(1)

The primary ligand for AT2. Its presence may modulate the expression of AT2 receptors in a feedback mechanism.

Losartan

114798-26-4sc-353662
100 mg
$127.00
18
(1)

An angiotensin receptor blocker (ARB) that primarily targets AT1 but might indirectly influence AT2 expression.

Candesartan

139481-59-7sc-217825
sc-217825B
sc-217825A
10 mg
100 mg
1 g
$46.00
$92.00
$148.00
6
(1)

Another ARB that may have an indirect effect on AT2 expression through its action on AT1.

Lipopolysaccharide, E. coli O55:B5

93572-42-0sc-221855
sc-221855A
sc-221855B
sc-221855C
10 mg
25 mg
100 mg
500 mg
$96.00
$166.00
$459.00
$1615.00
12
(2)

Can induce inflammatory responses, potentially influencing AT2 expression in certain cell types.

Dexamethasone

50-02-2sc-29059
sc-29059B
sc-29059A
100 mg
1 g
5 g
$76.00
$82.00
$367.00
36
(1)

A glucocorticoid that might modulate AT2 expression in certain contexts.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$65.00
$319.00
$575.00
$998.00
28
(1)

Known to modulate cell differentiation and might influence AT2 receptor expression.

Telmisartan

144701-48-4sc-204907
sc-204907A
50 mg
100 mg
$71.00
$92.00
8
(1)

An ARB with unique PPAR-gamma activating properties that might influence AT2 expression.

Insulin

11061-68-0sc-29062
sc-29062A
sc-29062B
100 mg
1 g
10 g
$153.00
$1224.00
$12239.00
82
(1)

Can modulate various cellular pathways and might influence AT2 expression.

β-Estradiol

50-28-2sc-204431
sc-204431A
500 mg
5 g
$62.00
$178.00
8
(1)

Hormonal influence might modulate AT2 expression, especially in cardiovascular tissues.