Molecular structure of Telmisartan, CAS Number: 144701-48-4
Telmisartan (CAS 144701-48-4)
See product citations (8)
Alternate Names:
Micardis; Pritor; BIBR 277
Application:
Telmisartan is a nonpeptide angiotensin II receptor type 1 antagonist
CAS Number:
144701-48-4
Purity:
≥98%
Molecular Weight:
514.62
Molecular Formula:
C33H30N4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Telmisartan is utilized in studies centered on understanding its ability to modulate angiotensin II receptor activity, particularly in cardiovascular models. It is used to explore the pathways of hypertension and related cardiovascular conditions, focusing on how it interacts with the renin-angiotensin-aldosterone system (RAAS). Studies involving telmisartan also looks into its potential effects on metabolic syndrome, as it may influence insulin sensitivity and lipid metabolism. Telmisartan is of interest in studies investigating its potential to modulate peroxisome proliferator-activated receptor gamma (PPAR-γ) and its impact on various metabolic processes. Some also employ telmisartan in studies aimed at understanding its effect on endothelial function and its role in oxidative stress mechanisms.
Telmisartan (CAS 144701-48-4) References
- Telmisartan in high-risk cardiovascular patients. | Weber, MA. 2010. Am J Cardiol. 105: 36A-43A. PMID: 20102972
- Fenofibrate and Telmisartan in the Management of Abdominal Aortic Aneurysm. | Rowbotham, SE., et al. 2018. Curr Drug Targets. 19: 1241-1246. PMID: 29284388
- Telmisartan inhibits oxalate and calcium oxalate crystal-induced epithelial-mesenchymal transformation via PPAR-γ-AKT/STAT3/p38 MAPK-Snail pathway. | Liu, Y., et al. 2020. Life Sci. 241: 117108. PMID: 31786192
- Telmisartan-induced sprue-like enteropathy: a case report. | Alzueta, N., et al. 2020. Eur J Hosp Pharm. 27: 49-51. PMID: 32064089
- Telmisartan as tentative angiotensin receptor blocker therapeutic for COVID-19. | Rothlin, RP., et al. 2020. Drug Dev Res. 81: 768-770. PMID: 32356926
- Efficacy of telmisartan for the treatment of persistent renal proteinuria in dogs: A double-masked, randomized clinical trial. | Lourenço, BN., et al. 2020. J Vet Intern Med. 34: 2478-2496. PMID: 33165969
- Telmisartan prevents high-fat diet-induced neurovascular impairments and reduces anxiety-like behavior. | Huber, G., et al. 2021. J Cereb Blood Flow Metab. 41: 2356-2369. PMID: 33730932
- Effect of telmisartan, angiotensin-converting enzyme inhibition, or both, on proteinuria and blood pressure in dogs. | Fowler, BL., et al. 2021. J Vet Intern Med. 35: 1231-1237. PMID: 33769606
- Treatment of proteinuria in dogs with telmisartan: A retrospective study. | Lecavalier, J., et al. 2021. J Vet Intern Med. 35: 1810-1818. PMID: 33969924
- Telmisartan anti-cancer activities mechanism through targeting N-cadherin by mimicking ADH-1 function. | Khorsand, M., et al. 2022. J Cell Mol Med. 26: 2392-2403. PMID: 35224849
- Telmisartan is the most effective ARB to increase adiponectin via PPARα in adipocytes. | Hattori, N., et al. 2022. J Mol Endocrinol. 69: 259-268. PMID: 35354667
- Telmisartan ameliorates LPS-induced pneumonia in rats through regulation of the PPARγ/NF-κB pathway. | Zhou, X., et al. 2022. Microbiol Immunol. 66: 371-378. PMID: 35485217
- MicroRNA profiles following telmisartan treatment in pancreatic ductal adenocarcinoma cells. | Yamana, Y., et al. 2022. J Cancer Res Ther. 18: S305-S312. PMID: 36510981
- Pharmacological characterization of the novel nonpeptide angiotensin II receptor antagonist, BIBR 277. | Wienen, W., et al. 1993. Br J Pharmacol. 110: 245-52. PMID: 8220885
- Telmisartan. | McClellan, KJ. and Markham, A. 1998. Drugs. 56: 1039-44; discussion 1045-6. PMID: 9878991
Inhibitor of:
AGT1, AGTRAP, ANG III, ANG IV, Angiotensin, Angiotensinase C, AP1AR, AT1, AT1a, ATP-binding cassette sub-family A (ABCA), C/EBP δ, CES2, DGCR14, HRG-β3, Klkb16, MAS1L, NTCP, Oatp3, Oatp4, Olfr1095, Olfr250, Olfr770, Olfr771, Olr1432, Olr1470, Olr1472, Olr1479, Olr1499, Olr1511, Olr1517, Olr208, Olr32, Olr400, Olr402, Olr408, Olr409, Olr413, Olr418, Olr419, Olr420, Olr421, Olr424, Olr434, RENBP, S-antigen, SLC22A9, V1RA5, V1RA6, V1RA9, V2R11, Vasculin, Vmn1r155, and Vmn2r76.Activator of:
2900097C17Rik, AdipoR1, ANG IV, AT1, AT1a, AT2, B42, CTRP2, EG546325, EG624219, KLK1_Klk1, MAS1, MKP-4, and PPAR gamma.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Telmisartan, 50 mg | sc-204907 | 50 mg | $72.00 | |||
Telmisartan, 100 mg | sc-204907A | 100 mg | $94.00 |