ASXL3 Activators
ASXL3 Activators are a class of chemical compounds selected for their potential to enhance the functional activity of ASXL3, a key player in chromatin remodeling and transcriptional regulation. This group includes DNA methyltransferase inhibitors such as 5-Aza-2'-deoxycytidine and RG108, which can potentially boost ASXL3's role in the dynamic process of epigenetic modification and gene expression regulation. S-Adenosylmethionine (SAM), as a universal methyl donor, is critical for ASXL3's involvement in methylation processes, crucial for chromatin and gene regulation.
The EZH2 inhibitors (GSK126 and EPZ-6438), and UNC1999, which also targets EZH1, are included for their role in potentially modulating the interaction of ASXL3 with components of the polycomb repressive complex 2, influencing histone methylation and chromatin architecture. BIX-01294, targeting G9a histone methyltransferase, and JQ1, a BET bromodomain inhibitor, further emphasize ASXL3's involvement in broader chromatin organization and transcriptional regulatory processes. The Menin-MLL inhibitor, by affecting the MLL complex, underscores the potential of ASXL3 in gene expression regulation, particularly in the context of chromatin dynamics.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
DNA methyltransferase inhibitor, can enhance ASXL3's role in epigenetic regulation and gene expression. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
A methyl donor in methylation reactions, potentially augmenting ASXL3's methylation activity. | ||||||
GSK126 | 1346574-57-9 | sc-490133 sc-490133A sc-490133B | 1 mg 5 mg 10 mg | $92.00 $243.00 $306.00 | ||
Targets EZH2 methyltransferase, could influence ASXL3's interaction with polycomb repressive complex 2. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $37.00 $112.00 $408.00 | ||
G9a histone methyltransferase inhibitor, potentially enhancing ASXL3's regulatory role in histone methylation. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
BET bromodomain inhibitor, might impact ASXL3's function in chromatin organization and transcription regulation. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
DNA methyltransferase inhibitor, could enhance ASXL3's activity in DNA methylation and gene regulation. | ||||||
EPZ6438 | 1403254-99-8 | sc-507456 | 1 mg | $66.00 | ||
Selective EZH2 inhibitor, could modulate ASXL3's activity in chromatin remodeling. | ||||||
UNC1999 | 1431612-23-5 | sc-475314 | 5 mg | $142.00 | 1 | |
EZH1/EZH2 inhibitor, may influence ASXL3's involvement in histone methylation and gene expression."ASXL3 Activators" are a class of chemical compounds selected for their potential to enhance the functional activity of ASXL3, a key player in chromatin remodeling and transcriptional regulation. This group includes DNA methyltransferase inhibitors such as 5-Aza-2'-deoxycytidine and RG108, which can potentially boost ASXL3's role in the dynamic process of epigenetic modification and gene expression regulation. S-Adenosylmethionine (SAM), as a universal methyl donor, is critical for ASXL3's involvement in methylation processes, crucial for chromatin and gene regulation. | ||||||