ASGPR2 Activators
ASGPR2 Activators belong to a class of chemical compounds designed to modulate the activity of the Asialoglycoprotein Receptor 2 (ASGPR2), a protein primarily found on the surface of hepatocytes, or liver cells. The ASGPR2 receptor plays a crucial role in the recognition and clearance of desialylated glycoproteins from the bloodstream. These glycoproteins often arise from aging or damaged cells and can carry harmful molecules or pathogens. ASGPR2 Activators are designed to selectively enhance the function of this receptor, thereby promoting the efficient removal of desialylated glycoproteins from circulation.
The mechanism of action of ASGPR2 Activators involves binding to the ASGPR2 receptor, which subsequently triggers a cascade of intracellular events. This cascade leads to an increased uptake and degradation of desialylated glycoproteins within the hepatocytes, effectively reducing their presence in the bloodstream. By facilitating this process, ASGPR2 Activators contribute to the maintenance of overall health by aiding in the body's natural defense mechanisms against harmful substances. This class of compounds is of particular interest in the context of liver function and glycoprotein metabolism, as they offer potential avenues for manipulating these processes for various purposes. Further research in this area may yield insights into the broader implications of ASGPR2 activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Acts as a histone deacetylase inhibitor, potentially enhancing gene transcription of ASGPR2. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
A known differentiating agent that may upregulate ASGPR2 expression in certain cell types. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
A glucocorticoid that may stimulate ASGPR2 expression, possibly through its anti-inflammatory effects. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Elevates cAMP levels, which can activate signaling pathways leading to increased ASGPR2 expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
A polyphenol with potential epigenetic effects that could affect ASGPR2 expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
May activate Wnt signaling, which could contribute to ASGPR2 upregulation. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
A DNA demethylating agent that might influence ASGPR2 gene expression by reducing DNA methylation. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
An HDAC inhibitor that can promote histone acetylation, potentially leading to ASGPR2 gene activation. | ||||||
Betaine | 107-43-7 | sc-214595 sc-214595A sc-214595B sc-214595C sc-214595D sc-214595E | 50 g 100 g 250 g 1 kg 2.5 kg 5 kg | $31.00 $41.00 $56.00 $163.00 $337.00 $592.00 | 2 | |
May act as a methyl donor and participate in epigenetic regulation of ASGPR2 expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
An HDAC inhibitor that can modify chromatin structure, affecting ASGPR2 transcription. | ||||||