ARL13B Activators
ARL13B activators, in the context of this list, refer to a range of chemicals that indirectly influence the activity of ARL13B by modulating processes related to ciliogenesis, cilia maintenance, or associated signaling pathways. These activators do not bind directly to ARL13B but exert their effects on the cellular pathways and processes that are critical for the proper functioning of ARL13B.
The chemicals listed vary in their mechanisms of action. For example, Forskolin increases cAMP levels, which is a crucial signaling molecule in many cellular processes, including those that may affect ciliogenesis. Lithium Chloride and Roscovitine modulate signaling pathways (Wnt and cyclin-dependent kinase pathways, respectively) that are implicated in ciliary dynamics. Compounds like Rapamycin and Chloroquine act on cellular processes such as mTOR signaling and lysosomal function, which are indirectly connected to ciliary function and hence, ARL13B activity. Microtubule-targeting agents such as Vincristine, Paclitaxel, and Nocodazole affect the structural integrity and dynamics of cilia, which is central to ARL13B's role. Additionally, Cytochalasin D and Blebbistatin, by disrupting actin and inhibiting myosin II respectively, affect the cytoskeletal dynamics that can influence ciliary function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels, which can influence ciliary function and potentially impact ARL13B-related pathways. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3β, a negative regulator of the Wnt signaling pathway, which is implicated in ciliogenesis and may indirectly affect ARL13B. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine, a cyclin-dependent kinase inhibitor, can influence cilia disassembly and assembly processes, potentially impacting ARL13B function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR signaling, a pathway involved in cilia length regulation, potentially influencing ARL13B activity. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules, affecting ciliary dynamics and potentially impacting ARL13B. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
ZM-447439, an Aurora kinase inhibitor, affects ciliogenesis and may indirectly influence ARL13B function. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubules, affecting ciliary assembly and potentially impacting ARL13B. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D disrupts actin filaments, which can influence ciliary function and indirectly affect ARL13B. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
Blebbistatin inhibits myosin II, affecting cytoskeletal dynamics relevant to ciliogenesis, potentially impacting ARL13B. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 inhibits ROCK, affecting actin cytoskeleton dynamics and cilia formation, potentially impacting ARL13B. | ||||||