ARL11 Inhibitors
ARL11 inhibitors are chemical compounds that directly or indirectly influence the function of ARL11, a small GTPase known to regulate vesicle-mediated transport. Inhibitors such as Brefeldin A, Wortmannin, LY294002, Nocodazole, Vinblastine, Monensin, Chlorpromazine, Dynasore, Exo1, Pitstop 2, Latrunculin B, and Genistein can lead to the decreased functional activity of ARL11 through specific signaling pathways or biological processes that it is directly involved in. For instance, Brefeldin A inhibits protein transport from the endoplasmic reticulum to the Golgi apparatus, which can disrupt the formation and function of vesicles involved in ARL11-mediated transport. Wortmannin and LY294002, both PI3K inhibitors, can disrupt vesicle trafficking by inhibiting the PI3K-dependent pathway, a pathway that ARL11 is involved in.
Microtubule-disrupting agents such as Nocodazole and Vinblastine inhibit microtubule dynamics, leading to the disruption of vesicle transport along the microtubules, a process in which ARL11 is deeply involved. Monensin, a sodium ionophore, disrupts intracellular trafficking by altering ion gradients, a process that can disrupt the functional activity of ARL11. Chlorpromazine and Pitstop 2, both inhibitors of clathrin-mediated endocytosis, can also lead to decreased functional activity of ARL11 by disrupting vesicle-mediated transport. Dynasore and Exo1 inhibit the function of dynamin and the exocyst complex respectively, both crucial components in vesicle formation and trafficking, thereby leading to a decrease in ARL11's functional activity. Latrunculin B and Genistein, inhibitors of actin polymerization and tyrosine kinase respectively, can also disrupt intracellular processes leading to decreased ARL11 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A is a fungal metabolite that inhibits protein transport from the endoplasmic reticulum to the Golgi apparatus. ARL11 is involved in the regulation of vesicle-mediated transport, and the inhibition of protein transport by Brefeldin A can disrupt the formation and function of these vesicles, leading to decreased functional activity of ARL11. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor that can disrupt vesicle trafficking by inhibiting the PI3K-dependent pathway. As ARL11 is involved in vesicle trafficking, Wortmannin's inhibition of PI3K can lead to decreased functional activity of ARL11. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can disrupt vesicle trafficking by inhibiting the PI3K-dependent pathway. As ARL11 is involved in vesicle trafficking, LY294002's inhibition of PI3K can lead to decreased functional activity of ARL11. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole is a microtubule-depolymerizing agent. As ARL11 is involved in vesicle transport along microtubules, Nocodazole's depolymerization of microtubules can disrupt this transport process, leading to decreased functional activity of ARL11. | ||||||
Vinblastine Sulfate | 143-67-9 | sc-201447 sc-201447A sc-201447B sc-201447C | 10 mg 50 mg 100 mg 1 g | $107.00 $404.00 $550.00 $2200.00 | 9 | |
Vinblastine is a microtubule-disrupting agent that inhibits microtubule dynamics, leading to the disruption of vesicle transport along the microtubules. Since ARL11 is involved in vesicle transport, the disruption of microtubule dynamics by Vinblastine can lead to decreased functional activity of ARL11. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin is a sodium ionophore that disrupts intracellular trafficking by altering ion gradients. Given ARL11's role in vesicle trafficking, Monensin's alteration of ion gradients can disrupt the functional activity of ARL11. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Chlorpromazine inhibits clathrin-mediated endocytosis. As ARL11 is involved in the regulation of vesicle-mediated transport, Chlorpromazine's inhibition of clathrin-mediated endocytosis can lead to decreased functional activity of ARL11. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore inhibits the GTPase activity of dynamin, a protein involved in vesicle formation. ARL11's function in vesicle-mediated transport can be disrupted by Dynasore's effect on dynamin, leading to a decrease in ARL11's functional activity. | ||||||
Exo1 | 461681-88-9 | sc-200752 sc-200752A | 10 mg 50 mg | $82.00 $291.00 | 3 | |
Exo1 is an inhibitor of exocyst complex function. The inhibition of the exocyst complex can disrupt vesicle trafficking, a process in which ARL11 is involved, leading to a decrease in ARL11's functional activity. | ||||||
Pitstop 2 | 1419093-54-1 | sc-507418 | 10 mg | $360.00 | ||
Pitstop 2 is an inhibitor of clathrin-mediated endocytosis. As ARL11 is involved in vesicle-mediated transport, Pitstop 2's inhibition of clathrin-mediated endocytosis can decrease the functional activity of ARL11. | ||||||