ARL11 Activators
ARL11 activators include a diverse range of chemical compounds that influence various cellular processes and signaling pathways, ultimately affecting the function of ARL11. Phorbol 12-myristate 13-acetate, for instance, activates protein kinase C, which initiates a cascade of events leading to phosphorylation of key residues on ARL11 that enhance its functional activity. Similarly, Forskolin, by activating adenylate cyclase, leads to increased cAMP levels that upregulate the PKA pathway, which phosphorylates ARL11 at specific residues, ultimately enhancing its functional activity. The calcium ionophore A23187 and Ionomycin both manipulate calcium levels, a known regulator of calmodulin-dependent kinase pathways, and thereby can enhance the functionality of ARL11.
Bafilomycin A1, a specific inhibitor of vacuolar-type H+-ATPase, can enhance ARL11 activity by triggering protein folding changes in ARL11, enhancing its active conformation. Rapamycin, an inhibitor of mTOR, a master regulator of cellular metabolism, can also trigger AMPK pathways, which phosphorylate and activate ARL11. Chlorpromazine, a cationic amphiphilic drug, and Dynasore, a GTPase inhibitor, can both enhance ARL11 activity by increasing its availability at the plasma membrane. Wortmannin, a potent inhibitor of phosphoinositide 3-kinases implicated in endocytic pathways, can also enhance the activity of ARL11 by increasing its availability at theplasma membrane.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC). PKC activation initiates a cascade of events leading to phosphorylation of key residues on ARL11 that enhance its functional activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels. The surge in cAMP levels upregulates the PKA pathway, which phosphorylates ARL11 at specific residues, enhancing its functional activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels. The increased calcium levels trigger calmodulin-dependent kinase pathways which can phosphorylate ARL11, enhancing its functional activity. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 inhibits vacuolar-type H+-ATPase, leading to increased pH in the cytosol. The change in pH can trigger protein folding changes in ARL11, enhancing its active conformation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a master regulator of cellular metabolism. Inhibition of mTOR can trigger AMPK pathways, which phosphorylate and activate ARL11. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid inhibits protein phosphatases PP1 and PP2A. Inhibition of these phosphatases prevents the dephosphorylation of ARL11, maintaining it in an active state. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor. Its action can lead to compensatory upregulation of other kinases that phosphorylate and activate ARL11. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Increased calcium can trigger calmodulin-dependent kinase pathways, leading to the phosphorylation and activation of ARL11. | ||||||