ARK5 Inhibitors
ARK5 inhibitors represent a diverse class of chemicals that intricately modulate the intricate signaling pathways governed by the Atypical Kinase 5 (ARK5). Among these, staurosporine, a potent protein kinase inhibitor, directly competes with ATP binding at ARK5's catalytic site, disrupting its phosphorylation events and subsequently impacting cell survival and proliferation pathways. Sorafenib, originally a multi-kinase inhibitor, indirectly targets ARK5 by perturbing the RAF/MEK/ERK pathway, unraveling its role in inhibiting cancer cell progression. Several compounds, such as SB-203580 and SP600125, act as indirect inhibitors by targeting upstream components like p38 MAP kinase and JNK, respectively, altering ARK5 phosphorylation and influencing cellular processes. LY294002 and Rapamycin, inhibiting PI3K/AKT and mTOR pathways, indirectly modulate ARK5, shedding light on their intertwined regulatory mechanisms. Additionally, VX-745 and A-674563 selectively inhibit p38 MAP kinase and Akt1/2 kinase, respectively, impacting ARK5-mediated pathways related to inflammation and cell survival.
BAY 11-7082, a specific NF-κB inhibitor, indirectly influences ARK5 signaling, revealing the intricate connection between NF-κB activation and ARK5-regulated pathways. PD98059 and SB202190, targeting MEK and p38 MAP kinase, respectively, indirectly modulate ARK5, showcasing their roles in influencing cell cycle progression, apoptosis, and inflammation. GSK690693, a selective Akt inhibitor, uncovers the nuanced interplay between Akt and ARK5 in cellular regulation. This class of ARK5 inhibitors serves as a powerful toolkit for dissecting the complex web of signaling pathways, providing valuable insights into the biochemical tapestry woven by ARK5 in cellular homeostasis and disease progression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine, a potent protein kinase inhibitor, has been shown to inhibit ARK5 activity. It achieves this by competitively binding to the ATP-binding site of ARK5, disrupting its catalytic activity. This leads to the downregulation of ARK5-mediated signaling cascades, particularly those involved in cell survival and proliferation. Staurosporine's interference with ARK5 phosphorylation events influences downstream targets, impacting cellular processes that rely on ARK5 activation. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
Sorafenib, originally developed as a multi-kinase inhibitor, exhibits inhibitory effects on ARK5. By targeting various kinases in the RAF/MEK/ERK pathway, Sorafenib indirectly affects ARK5 signaling. Its interference with this pathway alters the phosphorylation patterns of ARK5, disrupting its normal cellular functions. The compound's impact on ARK5 adds an additional layer to its anticancer properties, as ARK5 is implicated in processes vital for cancer cell survival and progression. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB-203580 acts as a selective inhibitor of p38 MAP kinase, and its inhibition indirectly influences ARK5 activity. By targeting p38 MAP kinase, SB-203580 modulates downstream signaling events that intersect with ARK5-regulated pathways. This compound alters the phosphorylation status of ARK5, affecting its role in cell cycle regulation and apoptosis. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125, a well-known JNK inhibitor, indirectly impacts ARK5 signaling. By inhibiting JNK, SP600125 disrupts a signaling axis that converges with ARK5-regulated pathways. The altered phosphorylation state of ARK5 induced by SP600125 has downstream effects on cellular events, including apoptosis and cell cycle progression. The compound's specificity for JNK establishes it as a valuable tool for unraveling the intricate crosstalk between JNK and ARK5 in cellular regulation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, a potent PI3K inhibitor, indirectly influences ARK5 signaling through the PI3K/AKT pathway. By suppressing PI3K activity, LY294002 disrupts the phosphorylation events that contribute to ARK5 activation. This compound's impact on ARK5 alters its involvement in cellular processes related to survival and proliferation. The selective inhibition of PI3K by LY294002 provides insights into the intricate interplay between PI3K/AKT and ARK5 signaling cascades. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin, an mTOR inhibitor, indirectly affects ARK5 activity through the mTOR pathway. By inhibiting mTOR, Rapamycin modulates downstream events that intersect with ARK5-mediated signaling. The altered phosphorylation patterns of ARK5 induced by Rapamycin influence its role in cellular processes, including autophagy and cell growth. This compound's selectivity for mTOR highlights its utility in probing the functional connections between mTOR and ARK5 in cellular homeostasis. | ||||||
VX 745 | 209410-46-8 | sc-361401 sc-361401A | 10 mg 50 mg | $183.00 $842.00 | 4 | |
VX-745, a selective inhibitor of p38 MAP kinase, indirectly influences ARK5 signaling. By targeting p38 MAP kinase, VX-745 disrupts downstream events that intersect with ARK5-regulated pathways. The altered phosphorylation status of ARK5 induced by VX-745 impacts its involvement in cellular processes related to inflammation and apoptosis. | ||||||
A-674563 | 552325-73-2 | sc-364393 sc-364393A | 2 mg 5 mg | $232.00 $413.00 | ||
A-674563, a selective Akt1/2 kinase inhibitor, indirectly modulates ARK5 signaling through the Akt pathway. By inhibiting Akt1/2 kinase, A-674563 disrupts the phosphorylation events that contribute to ARK5 activation. The altered activation state of ARK5 induced by A-674563 influences its role in cellular processes, including cell survival and proliferation. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082, an inhibitor of NF-κB activation, indirectly influences ARK5 signaling through the NF-κB pathway. By suppressing NF-κB activation, BAY 11-7082 disrupts downstream events that intersect with ARK5-regulated pathways. The altered phosphorylation patterns of ARK5 induced by BAY 11-7082 impact its involvement in cellular processes related to inflammation and cell survival. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059, a selective MEK inhibitor, indirectly modulates ARK5 signaling through the MAPK pathway. By inhibiting MEK, PD98059 disrupts downstream events that intersect with ARK5-regulated pathways. The altered phosphorylation patterns of ARK5 induced by PD98059 influence its role in cellular processes related to cell cycle progression and apoptosis. | ||||||