ARK5 Activators
ARK5 activators constitute a diverse array of chemicals that intricately modulate the signaling pathways governed by Atypical Kinase 5 (ARK5), focusing on energy homeostasis and cellular survival. A-769662, an AMP-activated protein kinase (AMPK) activator, indirectly activates ARK5 by stimulating AMPK, initiating downstream effects on cellular processes related to energy homeostasis and survival. Mimicking AMP, AICAR serves as an indirect activator by promoting AMPK activation, influencing the intricate interplay between AMPK and ARK5 in cellular regulation. Metformin, an antidiabetic drug, indirectly activates ARK5 through AMPK stimulation, revealing its role in cellular processes related to metabolism and cell survival. Dorsomorphin, an AMPK inhibitor, acts as an indirect activator by disrupting normal AMPK-mediated phosphorylation events, providing insights into the interconnected signaling pathways governing cellular responses to energy stress. Salicylate, the active metabolite of aspirin, modulates ARK5 activity by activating AMPK, shedding light on the intricate interplay between metabolic stress and inflammation.
GW6471, a selective PPARα antagonist, indirectly influences ARK5 by modulating PPARα signaling, providing insights into the intricate interplay between lipid metabolism and ARK5-regulated pathways. Glucagon, a peptide hormone, indirectly activates ARK5 by stimulating AMPK, highlighting the interconnected signaling pathways governing cellular responses to nutrient availability. Leptin, a hormone involved in energy homeostasis, indirectly activates ARK5 by modulating AMPK signaling, unraveling the intricate interplay between hormonal regulation and ARK5 in cellular responses to metabolic cues. These chemicals serve as a powerful toolkit for dissecting the complex web of signaling pathways, providing valuable insights into the biochemical tapestry woven by ARK5 in cellular energetics and survival. The specificity of these activators for key components like AMPK, PPARα, and hormonal regulators emphasizes their role as targeted modulators, offering a nuanced understanding of ARK5-mediated cellular responses to diverse physiological cues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A-769662, an AMP-activated protein kinase (AMPK) activator, indirectly influences ARK5 activity. By activating AMPK, A-769662 modulates downstream signaling events that intersect with ARK5-regulated pathways. The altered phosphorylation patterns of ARK5 induced by A-769662 influence its role in cellular processes related to energy homeostasis and cell survival. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR (5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside), an AMP analog, indirectly activates ARK5 by stimulating AMPK. By mimicking AMP, AICAR promotes AMPK activation, leading to downstream effects on ARK5-regulated pathways. The altered phosphorylation patterns of ARK5 induced by AICAR influence its involvement in cellular processes related to energy sensing and cell survival. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin, a widely used antidiabetic drug, indirectly activates ARK5 by stimulating AMPK. Through its effects on cellular energy status, Metformin promotes AMPK activation, influencing downstream events that intersect with ARK5-regulated pathways. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $96.00 $355.00 | 69 | |
BML-275, a well-known AMPK inhibitor, can act as an indirect activator of ARK5. By inhibiting AMPK, Compound C disrupts the normal phosphorylation events that regulate ARK5 activity. The altered activation state of ARK5 induced by BML-275 influences its involvement in cellular processes related to energy homeostasis and cell survival. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-Deoxy-D-glucose, a glucose analog, indirectly activates ARK5 by influencing cellular energy metabolism. By disrupting glycolysis, 2-Deoxyglucose alters cellular energy status, leading to downstream effects on ARK5-regulated pathways. The altered phosphorylation patterns of ARK5 induced by 2-Deoxyglucose influence its role in cellular processes related to energy sensing and cell survival. . | ||||||
Dorsomorphin dihydrochloride | 1219168-18-9 | sc-361173 sc-361173A | 10 mg 50 mg | $186.00 $751.00 | 28 | |
Dorsomorphin, an AMPK inhibitor, indirectly influences ARK5 activity. By inhibiting AMPK, Dorsomorphin disrupts the normal phosphorylation events that regulate ARK5. The altered activation state of ARK5 induced by Dorsomorphin influences its involvement in cellular processes related to energy homeostasis and cell survival. This compound's specificity for AMPK inhibition positions it as a valuable tool for unraveling the intricate interplay between AMPK and ARK5 in cellular regulation. | ||||||
GW6471 | 880635-03-0 | sc-300779 | 5 mg | $295.00 | 9 | |
GW6471, a selective PPARα antagonist, indirectly influences ARK5 activity by modulating PPARα signaling. By inhibiting PPARα, GW6471 alters downstream events that intersect with ARK5-regulated pathways. The changed phosphorylation patterns of ARK5 induced by GW6471 influence its role in cellular processes related to lipid metabolism and cell survival. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $47.00 $94.00 $119.00 | 3 | |
Salicylic acid, the active metabolite of aspirin, indirectly influences ARK5 activity by modulating AMPK signaling. By activating AMPK, Salicylic acid alters downstream events that intersect with ARK5-regulated pathways. | ||||||