Date published: 2025-11-4

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arginase II Inhibitors

Arginase II inhibitors encompass a variety of compounds that directly or indirectly target the enzyme's activity, each acting through distinct mechanisms. Direct inhibitors such as Nω-Hydroxy-nor-L-arginine and Nor-NOHA effectively block arginase II by competing with its natural substrate, L-arginine, for the enzyme's active site. This mode of inhibition directly impairs the catalytic function of arginase II, highlighting the enzyme's substrate specificity and for targeted intervention. Similarly, L-lysine and L-ornithine serve as competitive inhibitors, binding to arginase II and hindering its ability to process L-arginine. These compounds demonstrate the efficacy of substrate competition as a strategy to inhibit arginase II activity.In contrast, compounds such as Bezafibrate, DFMO, Sildenafil, Simvastatin, Losartan, Dexamethasone, Aspirin, and Captopril modulate arginase II activity indirectly through various biological pathways. Bezafibrate, as a PPAR agonist, influences lipid metabolism, subsequently affecting arginase II expression. DFMO, targeting ornithine decarboxylase, impacts polyamine synthesis, indirectly altering arginase II function. Sildenafil, through enhancement of nitric oxide signaling, provides an alternative route to reduce arginase II activity. Statins like Simvastatin affect endothelial function, thereby modulating arginase II. Cardiovascular agents such as Losartan and Captopril alter the renin-angiotensin system, indirectly influencing arginase II activity. Anti-inflammatory compounds like Dexamethasone and Aspirin impact inflammatory pathways, which can in turn modulate arginase II activity. These diverse approaches to inhibiting arginase II underscore the complex regulation of the enzyme and the multiple pathways through which its activity can be modulated.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

BEC, Hydrochloride

sc-221291
5 mg
$345.00
(0)

BEC, Hydrochloride acts as an arginase II inhibitor, showcasing unique molecular interactions that disrupt the enzyme's active site. Its binding mechanism involves specific hydrogen bonding and hydrophobic interactions, which alter the enzyme's conformation and impede substrate access. The compound exhibits distinct reaction kinetics, characterized by a slow dissociation rate, allowing for sustained inhibition. Additionally, its solubility in various solvents enhances its reactivity in biochemical assays, making it a significant focus for research.

BEC

63107-40-4sc-205220
sc-205220A
1 mg
5 mg
$58.00
$197.00
(0)

BEC functions as an arginase II inhibitor through its ability to form stable complexes with the enzyme, effectively blocking substrate binding. The compound engages in specific electrostatic interactions that stabilize its binding, leading to a conformational shift in the enzyme. This results in altered catalytic efficiency and a unique kinetic profile, marked by a prolonged inhibition effect. Its diverse solubility properties facilitate its use in various experimental conditions, enhancing its role in biochemical studies.

N-ω-Hydroxy-L-norarginine diacetate salt

189302-40-7sc-476024
sc-476024A
25 mg
100 mg
$275.00
$627.00
(0)

A reversible inhibitor of arginase II, functions by competing with L-arginine for binding at the active site of the enzyme.

BEC ammonium salt

63107-40-4 (non-salt)sc-221290
sc-221290A
1 mg
5 mg
$75.00
$200.00
(0)

BEC ammonium salt acts as a selective arginase II modulator by engaging in unique hydrogen bonding and hydrophobic interactions with the enzyme's active site. This binding alters the enzyme's structural dynamics, resulting in a distinct alteration of its catalytic pathway. The compound exhibits a remarkable affinity for arginine, influencing reaction kinetics and leading to a notable decrease in enzymatic activity. Its versatile solubility enhances its compatibility in diverse biochemical environments, making it a valuable tool for research.

Bezafibrate

41859-67-0sc-204650B
sc-204650
sc-204650A
sc-204650C
500 mg
1 g
5 g
10 g
$30.00
$45.00
$120.00
$200.00
5
(1)

A peroxisome proliferator-activated receptor (PPAR) agonist, indirectly reduces ARG2 expression and activity by modulating lipid metabolism.

Difluoromethylornithine

70052-12-9sc-204723
sc-204723A
sc-204723B
sc-204723C
sc-204723D
sc-204723E
10 mg
25 mg
100 mg
250 mg
1 g
5 g
$58.00
$130.00
$158.00
$311.00
$964.00
$4726.00
2
(1)

Inhibits ornithine decarboxylase, leading to decreased polyamine synthesis, which indirectly affects arginase II activity.

Simvastatin

79902-63-9sc-200829
sc-200829A
sc-200829B
sc-200829C
50 mg
250 mg
1 g
5 g
$30.00
$87.00
$132.00
$434.00
13
(1)

A statin that lowers cholesterol levels; indirectly influences arginase II activity through modulation of endothelial function.

Losartan

114798-26-4sc-353662
100 mg
$127.00
18
(1)

Angiotensin II receptor antagonist; indirectly affects arginase II activity by modulating cardiovascular functions.

Dexamethasone

50-02-2sc-29059
sc-29059B
sc-29059A
100 mg
1 g
5 g
$76.00
$82.00
$367.00
36
(1)

Glucocorticoid that modulates inflammation and immune responses, potentially reducing arginase II activity.

Aspirin

50-78-2sc-202471
sc-202471A
5 g
50 g
$20.00
$41.00
4
(1)

Inhibits cyclooxygenases, leading to altered inflammatory response, which can indirectly affect arginase II activity.