Molecular structure of BEC ammonium salt, CAS Number: 63107-40-4 (non-salt)
BEC ammonium salt (CAS 63107-40-4 (non-salt))
Alternate Names:
S-(2-Boronoethyl)-L-cysteine . NH4
Application:
BEC ammonium salt is a slow-binding, competitive inhibitor of arginase I and II
CAS Number:
63107-40-4 (non-salt)
Purity:
≥95%
Molecular Weight:
210.07
Molecular Formula:
C5H11BNO4S•NH4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BEC ammonium salt is a slow-binding, competitive inhibitor of arginase I (Ki = 0.4-0.6 μM & KD = 2.22 μM for recombinant rat liver arginase) and arginase II (Ki = 0.31 μM at pH 7.5 and 0.03 μM at pH 9.5 for human recombinant type II arginase). BEC ammonium salt enhances NO-dependent smooth muscle relaxation in human penile corpus cavernosum tissue. BEC ammonium salt does not inhibit nitric oxide synthase (NOS) and may serve as a valuable reagent to probe the physiological relationship between arginase and NOS. BEC ammonium salt is also an inhibitor of rat aortic smooth muscle cell proliferation.
BEC ammonium salt (CAS 63107-40-4 (non-salt)) References
- Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. | Kim, NN., et al. 2001. Biochemistry. 40: 2678-88. PMID: 11258879
- Mechanistic and metabolic inferences from the binding of substrate analogues and products to arginase. | Cox, JD., et al. 2001. Biochemistry. 40: 2689-701. PMID: 11258880
- Elevated arginase I expression in rat aortic smooth muscle cells increases cell proliferation. | Wei, LH., et al. 2001. Proc Natl Acad Sci U S A. 98: 9260-4. PMID: 11470919
- Classical and slow-binding inhibitors of human type II arginase. | Colleluori, DM. and Ash, DE. 2001. Biochemistry. 40: 9356-62. PMID: 11478904
- Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels. | Berkowitz, DE., et al. 2003. Circulation. 108: 2000-6. PMID: 14517171
Inhibitor of:
arginase I, and arginase II.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BEC ammonium salt, 1 mg | sc-221290 | 1 mg | $75.00 | |||
BEC ammonium salt, 5 mg | sc-221290A | 5 mg | $200.00 |