BEC (CAS 63107-40-4)
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L-Arginine serves as a common substrate for both nitric oxide synthase (NOS) and arginase in the cell. NOS catalyzes the oxidation of arginine to citrulline and NO with Nω-hydroxy-L-arginine (NOHA) formed as an intermediate. Arginase, on the other hand, catalyzes the hydrolysis of arginine into urea and L-ornithine. BEC is a potent slow-binding competitive inhibitor of recombinant rat liver arginase I with a Ki of 0.4-0.6 µM.1 It is also a potent inhibitor of human arginase II with Ki values of 0.31 µM and 30 nM at pH 7.5 and 9.5, respectively.2 It does not inhibit murine iNOS at concentrations up to 1 mM. BEC significantly enhances NO-dependent relaxation of human penile corpus canvernosum smooth muscle in vitro at concentrations between 0.1-1.0 mM.1
BEC (CAS 63107-40-4) References
- Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. | Kim, NN., et al. 2001. Biochemistry. 40: 2678-88. PMID: 11258879
- Classical and slow-binding inhibitors of human type II arginase. | Colleluori, DM. and Ash, DE. 2001. Biochemistry. 40: 9356-62. PMID: 11478904
- Role of arginase in the male and female sexual arousal response. | Kim, NN., et al. 2004. J Nutr. 134: 2873S-2879S; discussion 2895S. PMID: 15465804
- Arginase-2 mediates diabetic renal injury. | Morris, SM., et al. 2011. Diabetes. 60: 3015-22. PMID: 21926276
- L-arginine uptake by cationic amino acid transporter 2 is essential for colonic epithelial cell restitution. | Singh, K., et al. 2012. Am J Physiol Gastrointest Liver Physiol. 302: G1061-73. PMID: 22361732
- Development of novel arginase inhibitors for therapy of endothelial dysfunction. | Steppan, J., et al. 2013. Front Immunol. 4: 278. PMID: 24062745
- Arginase Inhibitors: A Rational Approach Over One Century. | Pudlo, M., et al. 2017. Med Res Rev. 37: 475-513. PMID: 27862081
- Arginase-2 mediates renal ischemia-reperfusion injury. | Raup-Konsavage, WM., et al. 2017. Am J Physiol Renal Physiol. 313: F522-F534. PMID: 28515179
- L-citrulline increases arginase II protein levels and arginase activity in hypoxic piglet pulmonary artery endothelial cells. | Douglass, MS., et al. 2021. Pulm Circ. 11: 20458940211006289. PMID: 33948161
- Effects of arginase inhibition on myocardial Ca2+ and contractile responses. | Cho, JS., et al. 2022. Physiol Rep. 10: e15396. PMID: 35866269
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BEC, 1 mg | sc-205220 | 1 mg | $58.00 | |||
BEC, 5 mg | sc-205220A | 5 mg | $197.00 |