ArgBP2a Inhibitors
ArgBP2a inhibitors are a class of chemical compounds that specifically interact with and inhibit the function of ArgBP2a, a protein belonging to the sorbin and SH3 domain-containing family. ArgBP2a is known to be involved in cellular signaling pathways, acting as a scaffold protein that binds to other molecules, facilitating the assembly of multi-protein complexes. It has been shown to play a role in actin cytoskeleton dynamics, cellular adhesion, and various signal transduction processes. ArgBP2a inhibitors are designed to target specific domains of the protein, particularly its SH3 domains, which are responsible for binding to proline-rich sequences in other proteins. By inhibiting these interactions, ArgBP2a inhibitors can disrupt the formation of protein complexes, affecting downstream signaling pathways that rely on ArgBP2a as a scaffold.
The development of ArgBP2a inhibitors involves understanding the structural features of the protein, including the precise arrangement of its SH3 domains and their binding interfaces. Researchers use techniques such as crystallography and molecular modeling to identify key binding sites on ArgBP2a that can be targeted by inhibitory molecules. These inhibitors are typically small molecules or peptides that fit into the binding pockets of ArgBP2a, preventing it from interacting with its partner proteins. This selective inhibition provides valuable tools for studying the role of ArgBP2a in various cellular processes, including its involvement in actin filament organization and cell signaling dynamics. By disrupting its interactions, ArgBP2a inhibitors enable researchers to probe the specific contributions of this protein to cellular structure and function, providing insights into its biological significance across different cell types.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide may downregulate ArgBP2a by halting the elongation step during protein synthesis in eukaryotic cells, thereby preventing the assembly of ArgBP2a polypeptides. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
By binding to DNA and stalling RNA polymerase movement, Actinomycin D could decrease transcription levels of ArgBP2a, leading to diminished mRNA availability for translation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin has the potential to decrease ArgBP2a levels by inhibiting the mTOR pathway, which is crucial for the regulation of protein synthesis, possibly resulting in decreased ArgBP2a synthesis. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A could lead to the downregulation of ArgBP2a by preventing histone deacetylases from removing acetyl groups on histones, thereby altering gene expression patterns. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By incorporating into DNA and RNA, 5-Azacytidine may cause DNA hypomethylation, which could lead to the downregulation of ArgBP2a expression through changes in the epigenetic landscape. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea could reduce ArgBP2a levels by targeting ribonucleotide reductase, which is essential for DNA synthesis, potentially leading to a decrease in ArgBP2a gene transcription. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 may inhibit ArgBP2a expression by blocking the ubiquitin-proteasome pathway, which could trigger a buildup of misfolded proteins and cellular stress responses that decrease gene expression. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine may downregulate ArgBP2a by impairing lysosomal acidification, which is crucial for the autophagy process that can dictate the turnover rate of various cellular proteins. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
As a derivative of vitamin A, Retinoic acid could downregulate ArgBP2a by binding to retinoic acid receptors, which then bind to DNA, altering the transcriptional activity of certain genes. | ||||||
Wnt-C59 | 1243243-89-1 | sc-475634 sc-475634A sc-475634B | 5 mg 10 mg 50 mg | $210.00 $320.00 $1250.00 | 1 | |
Wnt-C59 may inhibit the expression of ArgBP2a by obstructing the Wnt signaling pathway, which is involved in controlling the transcriptional machinery of numerous genes. | ||||||