ARFGAP2 Activators
ARFGAP2, or ADP-ribosylation factor GTPase-activating protein 2, is an integral component of the cellular machinery that regulates vesicle trafficking, a vital process for intracellular transport and membrane dynamics. As a GTPase-activating protein (GAP), ARFGAP2 specifically accelerates the hydrolysis of GTP bound to ADP-ribosylation factors (ARFs), a family of small GTP-binding proteins pivotal in vesicle formation and the maintenance of organelle integrity.
The function of ARFGAP2 is crucial for the proper cycling of ARF proteins between their active and inactive states. When ARFs are active (GTP-bound), they can recruit coat proteins to membranes, initiating vesicle budding. ARFGAP2 induces the inactivation of ARFs (GDP-bound), causing the disassembly of coat proteins from vesicles, which is essential for vesicle fusion with target membranes.Through its role in vesicle trafficking, ARFGAP2 influences various aspects of cell physiology, including the secretion of proteins, lipid metabolism, and maintenance of the Golgi structure. It is also implicated in the regulation of cell growth and cytoskeletal organization, processes that are fundamental for cell division and migration.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin raises cAMP levels, which may lead to the upregulation of ARFGAP2 expression through activation of protein kinase A (PKA) signaling pathways. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid modulates gene expression through its receptors and could potentially increase ARFGAP2 expression as part of cellular differentiation processes. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
As a glucocorticoid, dexamethasone can modulate gene expression and might upregulate ARFGAP2 as part of the stress response. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in signaling pathways that can modulate gene expression, possibly including ARFGAP2. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This DNA methyltransferase inhibitor can cause demethylation of gene promoters, potentially leading to the activation of ARFGAP2 expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
As a histone deacetylase inhibitor, sodium butyrate can lead to chromatin remodeling and potentially increase the expression of ARFGAP2. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
β-Estradiol can influence gene expression through estrogen receptor signaling and may affect ARFGAP2 expression. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
As an inducer of oxidative stress, hydrogen peroxide can activate various signaling pathways that may lead to the upregulation of ARFGAP2. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has anti-inflammatory properties and may modulate the expression of genes involved in cell cycle regulation, including ARFGAP2. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol has been shown to affect gene expression and could potentially influence the expression of ARFGAP2 through its action on sirtuins and other signaling pathways. | ||||||