arfaptin 1 Inhibitors
Arfaptin 1 Inhibitors are a chemical class of compounds that target and modulate the activity of the Arfaptin 1 protein, also known as AFTPH, Arfaptin, or Centaurin-beta-4. Arfaptin 1 is a member of the Centaurin-beta family of proteins, which play a crucial role in intracellular vesicle trafficking, particularly in the regulation of endocytosis and vesicle formation. Structurally, Arfaptin 1 contains various domains, including a GTPase-activating protein (GAP) domain, a pleckstrin homology (PH) domain, and an Arfaptin homology (AH) domain, which enable it to interact with other proteins and membrane components involved in vesicle trafficking processes.
The functions of Arfaptin 1 are diverse and context-dependent, making it a central player in various cellular processes. One of its key roles is in the regulation of clathrin-mediated endocytosis, where it functions as an adaptor protein connecting clathrin-coated vesicles to the membrane and facilitating the formation of vesicles involved in receptor internalization. Additionally, Arfaptin 1 is implicated in the regulation of membrane dynamics and cytoskeletal rearrangements, affecting cellular processes such as cell migration and adhesion. Furthermore, Arfaptin 1 can interact with other signaling molecules and participate in cellular signaling pathways, potentially influencing cell growth and proliferation. The study of Arfaptin 1 Inhibitors involves the design of small molecules or compounds engineered to interfere with the interactions, membrane association, or function of Arfaptin 1, disrupting its role in intracellular vesicle trafficking and potentially influencing various cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D binds to DNA, inhibiting RNA synthesis. This would prevent the transcription of the ARFIP1 gene, thereby inhibiting Arfaptin 1 expression. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide inhibits protein synthesis by blocking translational elongation. This would prevent Arfaptin 1 synthesis post-transcription. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
α-Amanitin inhibits RNA polymerase II, preventing mRNA synthesis. This would inhibit the transcription of the ARFIP1 gene and thereby the expression of Arfaptin 1. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
DRB inhibits RNA polymerase II, preventing mRNA synthesis. This would inhibit the transcription of the ARFIP1 gene. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
Mycophenolic acid inhibits inosine monophosphate dehydrogenase, leading to decreased RNA synthesis and thus potentially reduced Arfaptin 1 expression. | ||||||
Puromycin dihydrochloride | 58-58-2 | sc-108071 sc-108071B sc-108071C sc-108071A | 25 mg 250 mg 1 g 50 mg | $40.00 $210.00 $816.00 $65.00 | 394 | |
Puromycin causes premature chain termination during translation, which would inhibit Arfaptin 1 synthesis. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin inhibits protein synthesis by blocking peptide bond formation. This would prevent Arfaptin 1 synthesis post-transcription. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin inhibits DNA topoisomerase I, leading to DNA damage and potentially reduced transcription of various genes, including ARFIP1. | ||||||
Harringtonin | 26833-85-2 | sc-204771 sc-204771A sc-204771B sc-204771C sc-204771D | 5 mg 10 mg 25 mg 50 mg 100 mg | $195.00 $350.00 $475.00 $600.00 $899.00 | 30 | |
Harringtonine inhibits protein synthesis by blocking the initiation step of translation, potentially reducing Arfaptin 1 synthesis. | ||||||
Acivicin | 42228-92-2 | sc-200498B sc-200498C sc-200498 sc-200498D | 1 mg 5 mg 10 mg 25 mg | $102.00 $408.00 $642.00 $1275.00 | 10 | |
Acivicin inhibits various enzymes involved in amino acid synthesis, potentially reducing protein synthesis, including Arfaptin 1. | ||||||